SNIP1

Smad nuclear interacting protein 1

Identifiers

SNIP1; FLJ12553; RP3-423B22.3; dJ423B22.2

External IDs

OMIM: 608241 MGI: 2156003 HomoloGene: 110886 GeneCards: SNIP1 Gene

Gene Ontology
Molecular function	• protein binding
Cellular component	• nucleus
Biological process	• regulation of transcription, DNA-dependent • I-kappaB kinase/NF-kappaB cascade • gene silencing by RNA • production of miRNAs involved in gene silencing by miRNA
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000163877

ENSMUSG00000050213

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
38 – 38.02 Mb

Chr 4:
124.74 – 124.75 Mb

PubMed search

Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene.^[1]^[2]^[3]

Interactions

SNIP1 has been shown to interact with EP300.^[1]

References

^ ^a ^b Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB (Aug 2000). "A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction". Genes Dev 14 (13): 1605–16. PMC 316742. PMID 10887155. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316742.
^ Roche KC, Wiechens N, Owen-Hughes T, Perkins ND (Oct 2004). "The FHA domain protein SNIP1 is a regulator of the cell cycle and cyclin D1 expression". Oncogene 23 (50): 8185–8195. doi:10.1038/sj.onc.1208025. PMID 15378006.
^ "Entrez Gene: SNIP1 Smad nuclear interacting protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79753.

Further reading

Kim RH, Flanders KC, Birkey Reffey S et al. (2002). "SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators". J. Biol. Chem. 276 (49): 46297–46304. doi:10.1074/jbc.M103819200. PMID 11567019.
Lin Y, Martin J, Gruendler C et al. (2002). "A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)". BMC Cell Biol. 3: 15. doi:10.1186/1471-2121-3-15. PMC 117437. PMID 12097147. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=117437.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–1332. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Cui Q, Lim SK, Zhao B, Hoffmann FM (2005). "Selective inhibition of TGF-beta responsive genes by Smad-interacting peptide aptamers from FoxH1, Lef1 and CBP". Oncogene 24 (24): 3864–3874. doi:10.1038/sj.onc.1208556. PMID 15750622.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. doi:10.1038/nature04209. PMID 16189514.
Olsen JV, Blagoev B, Gnad F et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Fujii M, Lyakh LA, Bracken CP et al. (2007). "SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes". Mol. Cell 24 (5): 771–783. doi:10.1016/j.molcel.2006.11.006. PMID 17157259.