SNAG1

Sorting nexin 18

Identifiers

SNX18; FLJ11997; FLJ32560; FLJ61062; MGC150827; MGC150829; SH3PX2; SH3PXD3B; SNAG1

External IDs

MGI: 2137642 HomoloGene: 14164 GeneCards: SNX18 Gene

Gene Ontology
Molecular function	• protein binding • lipid binding • phosphatidylinositol binding
Cellular component	• endosome • plasma membrane • endosome membrane • endomembrane system • clathrin-coated vesicle • extrinsic to internal side of plasma membrane
Biological process	• endocytosis • cell communication • protein transport • positive regulation of GTPase activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
53.81 – 53.84 Mb

Chr 13:
114.38 – 114.41 Mb

PubMed search

[1]

[2]

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.^[1]^[2]^[3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined.^[3]

References

^ Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta 1761 (8): 878–96. doi:10.1016/j.bbalip.2006.04.011. PMID 16782399.
^ Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J (Sep 2007). "A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells". FEBS Lett 581 (23): 4455–62. doi:10.1016/j.febslet.2007.08.025. PMID 17761170.
^ ^a ^b "Entrez Gene: SNAG1 sorting nexin associated golgi protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=112574.

Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558.
Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253. PMID 11736640. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222253.
Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. doi:10.1167/iovs.04-1380. PMID 15851553.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi:10.1074/jbc.M309909200. PMID 14679214.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026. PMID 11485546. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222026.

Sorting nexins

SNX-BAR	SNX1 · SNX2 · SNX4 · SNX5 · SNX6 · SNX7 · SNX8 · SNX9 · SNX18 · SNX30 · SNX32 · SNX33

SNX-PX	SNX3 · SNX10 · SNX11 · SNX12 · SNX16 · SNX20 · SNX21 · SNX22 · SNX24 · SNX29

SNX-Other	SNX13 · SNX14 · SNX15 · SNX17 · SNX19 · SNX23 · SNX25 · SNX26 · SNX27 · SNX28 · SNX31

Related articles	PX domain · BAR domain · Retromer

B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)

SNAG1

References

Further reading