| SN-38 | |
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Other names
7-Ethyl-10-hydroxy-camptothecin |
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| Identifiers | |
| CAS number | 86639-52-3 |
| PubChem | 104842 |
| ChemSpider | 94634 |
| UNII | 0H43101T0J |
| ChEMBL | CHEMBL837 |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C22H20N2O5 |
| Molar mass | 392.404 g/mol |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
SN-38 is the active metabolite of irinotecan (an analog of camptothecin - a topoisomerase I inhibitor); it is 200 times more active than irinotecan itself.
SN38 is metabolized via glucoronidation by UGT1A1.
The variant of UGT1A1 in ~10% of Caucasians which leads to poor metabolization of Irinotecan predicts Irinotecan toxicity, as it cannot be excreted from the body in its SN-38 form.
SN-38 is lost into the bile and feces. It can cause the symptoms of diarrhoea and myelosuppression experienced by ~25% of the patients administered Irinotecan.