SMARCE1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1

Identifiers

SMARCE1; BAF57; FLJ35648

External IDs

OMIM: 603111 MGI: 1927347 HomoloGene: 37727 GeneCards: SMARCE1 Gene

Gene Ontology
Molecular function	• DNA binding • chromatin binding • transcription coactivator activity • protein binding • N-acetyltransferase activity • protein N-terminus binding
Cellular component	• nuclear chromosome • soluble fraction • nucleus • nucleolus • SWI/SNF complex • transcriptional repressor complex • npBAF complex • nBAF complex
Biological process	• nucleosome disassembly • regulation of transcription from RNA polymerase II promoter • nervous system development • chromatin modification • negative regulation of transcription, DNA-dependent
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
38.78 – 38.82 Mb

Chr 11:
99.07 – 99.09 Mb

PubMed search

[1]

[2]

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 is a protein that in humans is encoded by the SMARCE1 gene.^[1]^[2]

The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart.^[2]

Interactions

SMARCE1 has been shown to interact with Estrogen receptor alpha,^[3] SMARCB1^[4]^[5] and SMARCA4.^[4]^[5]

References

^ Wang W, Chi T, Xue Y, Zhou S, Kuo A, Crabtree GR (Feb 1998). "Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes". Proc Natl Acad Sci U S A 95 (2): 492–8. doi:10.1073/pnas.95.2.492. PMC 18447. PMID 9435219. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=18447.
^ ^a ^b "Entrez Gene: SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6605.
^ Belandia, Borja; Orford Rob L, Hurst Helen C, Parker Malcolm G (Aug. 2002). "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes". EMBO J. (England) 21 (15): 4094–103. doi:10.1093/emboj/cdf412. ISSN 0261-4189. PMC 126156. PMID 12145209. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126156.
^ ^a ^b Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (Oct. 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. (ENGLAND) 15 (19): 5370–82. ISSN 0261-4189. PMC 452280. PMID 8895581. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452280.
^ ^a ^b Zhao, K; Wang W, Rando O J, Xue Y, Swiderek K, Kuo A, Crabtree G R (Nov. 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell (UNITED STATES) 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. ISSN 0092-8674. PMID 9845365.

Martens JA, Winston F (2003). "Recent advances in understanding chromatin remodeling by Swi/Snf complexes". Curr. Opin. Genet. Dev. 13 (2): 136–42. doi:10.1016/S0959-437X(03)00022-4. PMID 12672490.
Wang W, Côté J, Xue Y, et al. (1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. 15 (19): 5370–82. PMC 452280. PMID 8895581. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452280.
Cho H, Orphanides G, Sun X, et al. (1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. 18 (9): 5355–63. PMC 109120. PMID 9710619. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109120.
Phelan ML, Sif S, Narlikar GJ, Kingston RE (1999). "Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits". Mol. Cell 3 (2): 247–53. doi:10.1016/S1097-2765(00)80315-9. PMID 10078207.
Xue Y, Canman JC, Lee CS, et al. (2001). "The human SWI/SNF-B chromatin-remodeling complex is related to yeast Rsc and localizes at kinetochores of mitotic chromosomes". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13015–20. doi:10.1073/pnas.240208597. PMC 27170. PMID 11078522. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=27170.
Decristofaro MF, Betz BL, Rorie CJ, et al. (2001). "Characterization of SWI/SNF protein expression in human breast cancer cell lines and other malignancies". J. Cell. Physiol. 186 (1): 136–45. doi:10.1002/1097-4652(200101)186:1<136::AID-JCP1010>3.0.CO;2-4. PMID 11147808.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
Kato H, Tjernberg A, Zhang W, et al. (2002). "SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones". J. Biol. Chem. 277 (7): 5498–505. doi:10.1074/jbc.M108702200. PMID 11734557.
Chi TH, Wan M, Zhao K, et al. (2002). "Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes". Nature 418 (6894): 195–9. doi:10.1038/nature00876. PMID 12110891.
Belandia B, Orford RL, Hurst HC, Parker MG (2002). "Targeting of SWI/SNF chromatin remodelling complexes to estrogen-responsive genes". EMBO J. 21 (15): 4094–103. doi:10.1093/emboj/cdf412. PMC 126156. PMID 12145209. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126156.
Battaglioli E, Andrés ME, Rose DW, et al. (2002). "REST repression of neuronal genes requires components of the hSWI.SNF complex". J. Biol. Chem. 277 (43): 41038–45. doi:10.1074/jbc.M205691200. PMID 12192000.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Baker KM, Wei G, Schaffner AE, Ostrowski MC (2003). "Ets-2 and components of mammalian SWI/SNF form a repressor complex that negatively regulates the BRCA1 promoter". J. Biol. Chem. 278 (20): 17876–84. doi:10.1074/jbc.M209480200. PMID 12637547.
Kitagawa H, Fujiki R, Yoshimura K, et al. (2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. PMID 12837248.
Hsiao PW, Fryer CJ, Trotter KW, et al. (2003). "BAF60a Mediates Critical Interactions between Nuclear Receptors and the BRG1 Chromatin-Remodeling Complex for Transactivation". Mol. Cell. Biol. 23 (17): 6210–20. doi:10.1128/MCB.23.17.6210-6220.2003. PMC 180928. PMID 12917342. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=180928.
Wu K, Bottazzi ME, de la Fuente C, et al. (2004). "Protein profile of tax-associated complexes". J. Biol. Chem. 279 (1): 495–508. doi:10.1074/jbc.M310069200. PMID 14530271.
Millar JK, Christie S, Porteous DJ (2004). "Yeast two-hybrid screens implicate DISC1 in brain development and function". Biochem. Biophys. Res. Commun. 311 (4): 1019–25. doi:10.1016/j.bbrc.2003.10.101. PMID 14623284.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

SMARCE1

Interactions

References

Further reading