SMARCC1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
Identifiers
Symbols SMARCC1; BAF155; CRACC1; Rsc8; SRG3; SWI3
External IDs OMIM: 601732 MGI: 1203524 HomoloGene: 68296 GeneCards: SMARCC1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6599 20588
Ensembl ENSG00000173473 ENSMUSG00000032481
UniProt Q92922 Q3UMX0
RefSeq (mRNA) NM_003074 NM_009211.2
RefSeq (protein) NP_003065 NP_033237.2
Location (UCSC) Chr 3:
47.63 – 47.82 Mb		 Chr 9:
110.03 – 110.14 Mb
PubMed search [1] [2]

SWI/SNF complex subunit SMARCC1 is a protein that in humans is encoded by the SMARCC1 gene.[1][2]

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors.[2]

Contents

Interactions

SMARCC1 has been shown to interact with BAZ1B,[3] SIN3A,[4][5] SMARCA2,[4][6] ING1,[5] SMARCB1[4][6] and SMARCA4.[4][6][7][8]

References

  1. ^ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (Nov 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes Dev 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307. 
  2. ^ a b "Entrez Gene: SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6599. 
  3. ^ Kitagawa, Hirochika; Fujiki Ryoji, Yoshimura Kimihiro, Mezaki Yoshihiro, Uematsu Yoshikatsu, Matsui Daisuke, Ogawa Satoko, Unno Kiyoe, Okubo Mataichi, Tokita Akifumi, Nakagawa Takeya, Ito Takashi, Ishimi Yukio, Nagasawa Hiromichi, Matsumoto Toshio, Yanagisawa Junn, Kato Shigeaki (Jun. 2003). "The chromatin-remodeling complex WINAC targets a nuclear receptor to promoters and is impaired in Williams syndrome". Cell (United States) 113 (7): 905–17. doi:10.1016/S0092-8674(03)00436-7. ISSN 0092-8674. PMID 12837248. 
  4. ^ a b c d Sif, S; Saurin A J, Imbalzano A N, Kingston R E (Mar. 2001). "Purification and characterization of mSin3A-containing Brg1 and hBrm chromatin remodeling complexes". Genes Dev. (United States) 15 (5): 603–18. doi:10.1101/gad.872801. ISSN 0890-9369. PMC 312641. PMID 11238380. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=312641. 
  5. ^ a b Kuzmichev, A; Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D (Feb. 2002). "Role of the Sin3-Histone Deacetylase Complex in Growth Regulation by the Candidate Tumor Suppressor p33ING1". Mol. Cell. Biol. (United States) 22 (3): 835–48. doi:10.1128/MCB.22.3.835-848.2002. ISSN 0270-7306. PMC 133546. PMID 11784859. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=133546. 
  6. ^ a b c Wang, W; Côté J, Xue Y, Zhou S, Khavari P A, Biggar S R, Muchardt C, Kalpana G V, Goff S P, Yaniv M, Workman J L, Crabtree G R (Oct. 1996). "Purification and biochemical heterogeneity of the mammalian SWI-SNF complex". EMBO J. (ENGLAND) 15 (19): 5370–82. ISSN 0261-4189. PMC 452280. PMID 8895581. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=452280. 
  7. ^ Otsuki, T; Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu J M (Nov. 2001). "Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex". Hum. Mol. Genet. (England) 10 (23): 2651–60. doi:10.1093/hmg/10.23.2651. ISSN 0964-6906. PMID 11726552. 
  8. ^ Zhao, K; Wang W, Rando O J, Xue Y, Swiderek K, Kuo A, Crabtree G R (Nov. 1998). "Rapid and phosphoinositol-dependent binding of the SWI/SNF-like BAF complex to chromatin after T lymphocyte receptor signaling". Cell (UNITED STATES) 95 (5): 625–36. doi:10.1016/S0092-8674(00)81633-5. ISSN 0092-8674. PMID 9845365. 

Further reading

External links