SMARCA4

Transcription activator BRG1 also known as ATP-dependent helicase SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.^[1]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44.^[2]

Clinical signficance

A high percent of inactivation of this gene has been found in human lung cancer cell lines.^[3]

Interactions

SMARCA4 has been shown to interact with Beta-catenin,^[4] SIN3A,^[5][6] Myc,^[7][8] CBX5,^[9] SMARCE1,^[10][11] HSP90B1,^[12] STAT2,^[13] CREB-binding protein,^[14][15] Glucocorticoid receptor,^[16][17] FANCA,^[12][18] STK11,^[19] BRCA1,^[20][21] ACTL6A,^[10][11] POLR2A,^[5][10][11] ING1,^[6] Cyclin E1,^[22][23] P53,^[24] Estrogen receptor alpha,^[25][14] Prohibitin,^[26] SMARCC2,^[10][12][11] SMARCC1,^{[5][10][12][11]} SMARCB1,^{[5][27][10][12][11]} ARID1B^[28][29] and ARID1A.^[10][11]

References

Further reading

External links

• FactorBook Brg1