SLIT1

Slit homolog 1 (Drosophila)

Identifiers

SLIT1; MEGF4; MGC164811; SLIL1; SLIT-1; SLIT3

External IDs

OMIM: 603742 MGI: 1315203 HomoloGene: 2302 GeneCards: SLIT1 Gene

Gene Ontology
Molecular function	• calcium ion binding • heparan sulfate proteoglycan binding • Roundabout binding
Cellular component	• extracellular region • extracellular space • cytoplasm
Biological process	• multicellular organismal development • nervous system development • axon guidance • axon guidance • brain development • motor axon guidance • spinal cord development • chemorepulsion involved in embryonic olfactory bulb interneuron migration • tangential migration from the subventricular zone to the olfactory bulb • cell differentiation • retinal ganglion cell axon guidance • dorsal/ventral axon guidance • establishment of nucleus localization • negative regulation of axon extension involved in axon guidance • axon extension involved in axon guidance • forebrain morphogenesis • negative chemotaxis • negative regulation of synaptogenesis
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 10:
98.76 – 98.95 Mb

Chr 19:
41.67 – 41.82 Mb

PubMed search

[1]

[2]

Slit homolog 1 protein is a protein that in humans is encoded by the SLIT1 gene.^[1]^[2]^[3]

References

^ Nakayama M, Nakajima D, Nagase T, Nomura N, Seki N, Ohara O (Sep 1998). "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Genomics 51 (1): 27–34. doi:10.1006/geno.1998.5341. PMID 9693030.
^ Itoh A, Miyabayashi T, Ohno M, Sakano S (Feb 1999). "Cloning and expressions of three mammalian homologues of Drosophila slit suggest possible roles for Slit in the formation and maintenance of the nervous system". Brain Res Mol Brain Res 62 (2): 175–186. doi:10.1016/S0169-328X(98)00224-1. PMID 9813312.
^ "Entrez Gene: SLIT1 slit homolog 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6585.

Nakajima D, Okazaki N, Yamakawa H et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Wong K, Park HT, Wu JY, Rao Y (2003). "Slit proteins: molecular guidance cues for cells ranging from neurons to leukocytes". Curr. Opin. Genet. Dev. 12 (5): 583–591. doi:10.1016/S0959-437X(02)00343-X. PMID 12200164.
Liang Y, Annan RS, Carr SA et al. (1999). "Mammalian homologues of the Drosophila slit protein are ligands of the heparan sulfate proteoglycan glypican-1 in brain". J. Biol. Chem. 274 (25): 17885–17892. doi:10.1074/jbc.274.25.17885. PMID 10364234.
Wu W, Wong K, Chen J et al. (1999). "Directional guidance of neuronal migration in the olfactory system by the protein Slit". Nature 400 (6742): 331–336. doi:10.1038/22477. PMC 2041931. PMID 10432110. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2041931.
Yuan W, Zhou L, Chen JH et al. (1999). "The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance". Dev. Biol. 212 (2): 290–306. doi:10.1006/dbio.1999.9371. PMID 10433822.
Little M, Rumballe B, Georgas K et al. (2003). "Conserved modularity and potential for alternate splicing in mouse and human Slit genes". Int. J. Dev. Biol. 46 (4): 385–91. PMID 12141424.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hammond R, Vivancos V, Naeem A et al. (2005). "Slit-mediated repulsion is a key regulator of motor axon pathfinding in the hindbrain". Development 132 (20): 4483–4495. doi:10.1242/dev.02038. PMID 16162649.
Lim J, Hao T, Shaw C et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell 125 (4): 801–814. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Lin L, Isacson O (2006). "Axonal growth regulation of fetal and embryonic stem cell-derived dopaminergic neurons by Netrin-1 and Slits". Stem Cells 24 (11): 2504–2513. doi:10.1634/stemcells.2006-0119. PMC 2613222. PMID 16840550. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2613222.
Hussain SA, Piper M, Fukuhara N et al. (2007). "A molecular mechanism for the heparan sulfate dependence of slit-robo signaling". J. Biol. Chem. 281 (51): 39693–39698. doi:10.1074/jbc.M609384200. PMID 17062560.

SLIT1

References

Further reading