SLC5A6

Solute carrier family 5 (sodium-dependent vitamin transporter), member 6

Identifiers

External IDs

OMIM: 604024 MGI: 2660847 HomoloGene: 23277 GeneCards: SLC5A6 Gene

Gene Ontology
Molecular function	• transporter activity • sodium-dependent multivitamin transmembrane transporter activity • symporter activity
Cellular component	• membrane fraction • plasma membrane • integral to plasma membrane • vesicle membrane • brush border membrane
Biological process	• vitamin metabolic process • water-soluble vitamin metabolic process • biotin metabolic process • transport • ion transport • sodium ion transport • biotin transport • pantothenate transmembrane transport • pantothenate metabolic process • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
27.42 – 27.44 Mb

Chr 5:
31.34 – 31.35 Mb

PubMed search

[1]

[2]

Sodium-dependent multivitamin transporter is a protein that in humans is encoded by the SLC5A6 gene.^[1]^[2]^[3]

References

^ Prasad PD, Wang H, Kekuda R, Fujita T, Fei YJ, Devoe LD, Leibach FH, Ganapathy V (Apr 1998). "Cloning and functional expression of a cDNA encoding a mammalian sodium-dependent vitamin transporter mediating the uptake of pantothenate, biotin, and lipoate". J Biol Chem 273 (13): 7501–6. doi:10.1074/jbc.273.13.7501. PMID 9516450.
^ Wang H, Huang W, Fei YJ, Xia H, Yang-Feng TL, Leibach FH, Devoe LD, Ganapathy V, Prasad PD (Jul 1999). "Human placental Na+-dependent multivitamin transporter. Cloning, functional expression, gene structure, and chromosomal localization". J Biol Chem 274 (21): 14875–83. doi:10.1074/jbc.274.21.14875. PMID 10329687.
^ "Entrez Gene: SLC5A6 solute carrier family 5 (sodium-dependent vitamin transporter), member 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8884.

Prasad PD, Wang H, Huang W, et al. (1999). "Molecular and functional characterization of the intestinal Na+-dependent multivitamin transporter.". Arch. Biochem. Biophys. 366 (1): 95–106. doi:10.1006/abbi.1999.1213. PMID 10334869.
Zempleni J, Steven Stanley J, Mock DM (2001). "Proliferation of peripheral blood mononuclear cells causes increased expression of the sodium-dependent multivitamin transporter gene and increased uptake of pantothenic acidopen star". The Journal of nutritional biochemistry 12 (8): 465–473. doi:10.1016/S0955-2863(01)00162-0. PMID 11834205.
Dey S, Subramanian VS, Chatterjee NS, et al. (2002). "Characterization of the 5' regulatory region of the human sodium-dependent multivitamin transporter, hSMVT.". Biochim. Biophys. Acta 1574 (2): 187–92. PMID 11955628.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Balamurugan K, Ortiz A, Said HM (2003). "Biotin uptake by human intestinal and liver epithelial cells: role of the SMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 285 (1): G73–7. doi:10.1152/ajpgi.00059.2003. PMID 12646417.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Balamurugan K, Vaziri ND, Said HM (2005). "Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects". Am. J. Physiol. Renal Physiol. 288 (4): F823–31. doi:10.1152/ajprenal.00375.2004. PMID 15561972.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Luo S, Kansara VS, Zhu X, et al. (2006). "Functional Characterization of Sodium-dependent Multivitamin Transporter (SMVT) in MDCK-MDR1 cells and its Utilization as a Target for Drug Delivery". Mol. Pharm. 3 (3): 329–39. doi:10.1021/mp0500768. PMC 2553563. PMID 16749865. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2553563.
Reidling JC, Nabokina SM, Said HM (2007). "Molecular mechanisms involved in the adaptive regulation of human intestinal biotin uptake: A study of the hSMVT system". Am. J. Physiol. Gastrointest. Liver Physiol. 292 (1): G275–81. doi:10.1152/ajpgi.00327.2006. PMID 16959947.
Reidling JC, Said HM (2007). "Regulation of the human biotin transporter hSMVT promoter by KLF-4 and AP-2: confirmation of promoter activity in vivo". Am. J. Physiol., Cell Physiol. 292 (4): C1305–12. doi:10.1152/ajpcell.00360.2006. PMID 17135299.

SLC5A6

References

Further reading