SLC13A2

Solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2

Identifiers

SLC13A2; NADC1; NaCT; NaDC-1; SDCT1

External IDs

OMIM: 604148 MGI: 1276558 HomoloGene: 2965 GeneCards: SLC13A2 Gene

Gene Ontology
Molecular function	• transporter activity • symporter activity • low affinity sodium:dicarboxylate symporter activity
Cellular component	• membrane fraction • plasma membrane • integral to plasma membrane
Biological process	• transport • ion transport • sodium ion transport • transmembrane transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
26.8 – 26.82 Mb

Chr 11:
78.21 – 78.24 Mb

PubMed search

[1]

[2]

Solute carrier family 13 member 2 is a protein that in humans is encoded by the SLC13A2 gene.^[1]^[2]^[3]

References

^ Pajor AM (Dec 1996). "Molecular cloning and functional expression of a sodium-dicarboxylate cotransporter from human kidney". Am J Physiol 270 (4 Pt 2): F642–8. PMID 8967342.
^ Mann SS, Hart TC, Pettenati MJ, von Kap-herr C, Holmes RP (Jun 1999). "Assignment of the sodium-dependent dicarboxylate transporter gene (SLC13A2 alias NaDC-1) to human chromosome region 17p11.1→q11.1 by radiation hybrid mapping and fluorescence in situ hybridization". Cytogenet Cell Genet 84 (1-2): 89–90. doi:10.1159/000015222. PMID 10343111.
^ "Entrez Gene: SLC13A2 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9058.

Inoue K, Zhuang L, Ganapathy V (2003). "Human Na+ -coupled citrate transporter: primary structure, genomic organization, and transport function.". Biochem. Biophys. Res. Commun. 299 (3): 465–71. doi:10.1016/S0006-291X(02)02669-4. PMID 12445824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Bai X, Chen X, Fen Z, et al. (2005). "Expression of EGFP/SDCT1 fusion protein, subcellular localization signal analysis, tissue distribution and electrophysiological function study.". Sci. China, C, Life Sci. 47 (6): 530–9. PMID 15620109.
Pajor AM, Randolph KM (2005). "Conformationally sensitive residues in extracellular loop 5 of the Na+/dicarboxylate co-transporter.". J. Biol. Chem. 280 (19): 18728–35. doi:10.1074/jbc.M501265200. PMC 1224748. PMID 15774465. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1224748.
Okamoto N, Aruga S, Matsuzaki S, et al. (2007). "Associations between renal sodium-citrate cotransporter (hNaDC-1) gene polymorphism and urinary citrate excretion in recurrent renal calcium stone formers and normal controls.". Int. J. Urol. 14 (4): 344–9. doi:10.1111/j.1442-2042.2007.01554.x. PMID 17470169.

SLC13A2

References

Further reading