SKIP
SKIP is an acronym for Skeletal muscle and kidney enriched inositol phosphatase, which is a human gene.[1]
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternative splicing of this gene results in two transcript variants encoding different isoforms.[1]
References
Further reading
- Drayer AL, Pesesse X, De Smedt F, et al. (1997). "The family of inositol and phosphatidylinositol polyphosphate 5-phosphatases.". Biochem. Soc. Trans. 24 (4): 1001–5. PMID 8968500.
- Mitchell CA, Brown S, Campbell JK, et al. (1997). "Regulation of second messengers by the inositol polyphosphate 5-phosphatases.". Biochem. Soc. Trans. 24 (4): 994–1000. PMID 8968499.
- Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Chen J, Xu J, Zhao W, et al. (2005). "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas.". Int. J. Biochem. Cell Biol. 37 (11): 2273–83. doi:10.1016/j.biocel.2005.02.028. PMID 16002321.
- Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180354.
- Ijuin T, Takenawa T (2003). "SKIP negatively regulates insulin-induced GLUT4 translocation and membrane ruffle formation.". Mol. Cell. Biol. 23 (4): 1209–20. doi:10.1128/MCB.23.4.1209-1220.2003. PMC 141139. PMID 12556481. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=141139.
- Gurung R, Tan A, Ooms LM, et al. (2003). "Identification of a novel domain in two mammalian inositol-polyphosphate 5-phosphatases that mediates membrane ruffle localization. The inositol 5-phosphatase skip localizes to the endoplasmic reticulum and translocates to membrane ruffles following epidermal growth factor stimulation.". J. Biol. Chem. 278 (13): 11376–85. doi:10.1074/jbc.M209991200. PMID 12536145.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ijuin T, Mochizuki Y, Fukami K, et al. (2000). "Identification and characterization of a novel inositol polyphosphate 5-phosphatase.". J. Biol. Chem. 275 (15): 10870–5. doi:10.1074/jbc.275.15.10870. PMID 10753883.