SHPRH

SNF2 histone linker PHD RING helicase

Identifiers

SHPRH; FLJ27258; FLJ37625; FLJ45012; FLJ90837; KIAA2023; MGC134886; bA545I5.2

External IDs

OMIM: 608048 MGI: 1917581 HomoloGene: 6489 GeneCards: SHPRH Gene

Gene Ontology
Molecular function	• nucleotide binding • DNA binding • helicase activity • ATP binding • zinc ion binding • hydrolase activity • ligase activity • metal ion binding
Cellular component	• nucleosome • nucleus
Biological process	• DNA repair • nucleosome assembly
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 6:
146.19 – 146.29 Mb

Chr 10:
10.87 – 10.94 Mb

PubMed search

[1]

[2]

E3 ubiquitin-protein ligase SHPRH is an enzyme that in humans is encoded by the SHPRH gene.^[1]^[2]

SHPRH is a ubiquitously expressed protein that contains motifs characteristics of several DNA repair proteins, transcription factors, and helicases.[supplied by OMIM]^[2]

References

^ Sood R, Makalowska I, Galdzicki M, Hu P, Eddings E, Robbins CM, Moses T, Namkoong J, Chen S, Trent JM (Jul 2003). "Cloning and characterization of a novel gene, SHPRH, encoding a conserved putative protein with SNF2/helicase and PHD-finger domains from the 6q24 region". Genomics 82 (2): 153–61. doi:10.1016/S0888-7543(03)00121-6. PMID 12837266.
^ ^a ^b "Entrez Gene: SHPRH SNF2 histone linker PHD RING helicase". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=257218.

Motegi A, Sood R, Moinova H et al. (2007). "Human SHPRH suppresses genomic instability through proliferating cell nuclear antigen polyubiquitination". J. Cell Biol. 175 (5): 703–8. doi:10.1083/jcb.200606145. PMC 2064669. PMID 17130289. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2064669.
Unk I, Hajdú I, Fátyol K et al. (2007). "Human SHPRH is a ubiquitin ligase for Mms2–Ubc13-dependent polyubiquitylation of proliferating cell nuclear antigen". Proc. Natl. Acad. Sci. U.S.A. 103 (48): 18107–12. doi:10.1073/pnas.0608595103. PMC 1838714. PMID 17108083. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1838714.
Stelzl U, Worm U, Lalowski M et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Jin J, Smith FD, Stark C et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Adams MD, Kerlavage AR, Fleischmann RD et al. (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature 377 (6547 Suppl): 3–174. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf.

SHPRH

References

Further reading