SH3GL3

SH3-domain GRB2-like 3

PDB rendering based on 2ew3.

Available structures
PDB	2EW3, 2Z0V

Identifiers

Symbols

SH3GL3; CNSA3; EEN-2B-L3; EEN-B2; HsT19371; SH3D2C; SH3P13

External IDs

OMIM: 603362 MGI: 700011 HomoloGene: 37723 GeneCards: SH3GL3 Gene

Gene Ontology
Molecular function	• protein binding • lipid binding • identical protein binding
Cellular component	• cytoplasm • endosome • membrane • early endosome membrane
Biological process	• endocytosis • signal transduction • central nervous system development
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
84.12 – 84.29 Mb

Chr 7:
89.32 – 89.46 Mb

PubMed search

[1]

[2]

Endophilin-A3 is a protein that in humans is encoded by the SH3GL3 gene.^[1]^[2]

Interactions

SH3GL3 has been shown to interact with Huntingtin^[3] and SH3KBP1.^[4]

References

^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
^ "Entrez Gene: SH3GL3 SH3-domain GRB2-like 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6457.
^ Sittler, A; Wälter S, Wedemeyer N, Hasenbank R, Scherzinger E, Eickhoff H, Bates G P, Lehrach H, Wanker E E (Oct. 1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates". Mol. Cell (UNITED STATES) 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. ISSN 1097-2765. PMID 9809064.
^ Petrelli, Annalisa; Gilestro Giorgio F, Lanzardo Stefania, Comoglio Paolo M, Migone Nicola, Giordano Silvia (Mar. 2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met". Nature (England) 416 (6877): 187–90. doi:10.1038/416187a. ISSN 0028-0836. PMID 11894096.

So CW, Caldas C, Liu MM, et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. doi:10.1073/pnas.94.6.2563. PMC 20128. PMID 9122235. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20128.
Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. doi:10.1073/pnas.94.16.8569. PMC 23017. PMID 9238017. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=23017.
Sittler A, Wälter S, Wedemeyer N, et al. (1998). "SH3GL3 associates with the Huntingtin exon 1 protein and promotes the formation of polygln-containing protein aggregates.". Mol. Cell 2 (4): 427–36. doi:10.1016/S1097-2765(00)80142-2. PMID 9809064.
Tang Y, Hu LA, Miller WE, et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMC 22990. PMID 10535961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22990.
Cestra G, Castagnoli L, Dente L, et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.". J. Biol. Chem. 274 (45): 32001–7. doi:10.1074/jbc.274.45.32001. PMID 10542231.
So CW, So CK, Cheung N, et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.". Leukemia 14 (4): 594–601. doi:10.1038/sj.leu.2401692. PMID 10764144.
So CW, Sham MH, Chew SL, et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.". Biochem. J.. 348 Pt 2 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085. PMID 10816441. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221085.
Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
Chatellard-Causse C, Blot B, Cristina N, et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747.
Verdier F, Valovka T, Zhyvoloup A, et al. (2002). "Ruk is ubiquitinated but not degraded by the proteasome.". Eur. J. Biochem. 269 (14): 3402–8. doi:10.1046/j.1432-1033.2002.03031.x. PMID 12135478.
Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
Otsuki M, Itoh T, Takenawa T (2003). "Neural Wiskott-Aldrich syndrome protein is recruited to rafts and associates with endophilin A in response to epidermal growth factor.". J. Biol. Chem. 278 (8): 6461–9. doi:10.1074/jbc.M207433200. PMID 12477732.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Yam JW, Jin DY, So CW, Chan LC (2004). "Identification and characterization of EBP, a novel EEN binding protein that inhibits Ras signaling and is recruited into the nucleus by the MLL-EEN fusion protein.". Blood 103 (4): 1445–53. doi:10.1182/blood-2003-07-2452. PMID 14551139.
Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease.". Mol. Cell 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
Trevaskis J, Walder K, Foletta V, et al. (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance.". Endocrinology 146 (9): 3757–64. doi:10.1210/en.2005-0282. PMID 15919751.
Ralser M, Nonhoff U, Albrecht M, et al. (2005). "Ataxin-2 and huntingtin interact with endophilin-A complexes to function in plastin-associated pathways.". Hum. Mol. Genet. 14 (19): 2893–909. doi:10.1093/hmg/ddi321. PMID 16115810.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.

PDB gallery

2ew3: Solution Structure Of The SH3 Domain Of Human SH3GL3

SH3GL3

Interactions

References

Further reading