SH3GL2

SH3-domain GRB2-like 2

PDB rendering based on 1x03.

Available structures
PDB	1X03, 1X04, 2D4C, 2DBM

Identifiers

Symbols

SH3GL2; CNSA2; EEN-B1; FLJ20276; FLJ25015; SH3D2A; SH3P4

External IDs

OMIM: 604465 MGI: 700009 HomoloGene: 20652 GeneCards: SH3GL2 Gene

Gene Ontology
Molecular function	• protein binding • lipid binding • identical protein binding
Cellular component	• Golgi membrane • cytoplasm • cytosol • cytosol • plasma membrane • plasma membrane
Biological process	• post-Golgi vesicle-mediated transport • endocytosis • signal transduction • epidermal growth factor receptor signaling pathway • axon guidance • central nervous system development • cellular membrane organization • negative regulation of epidermal growth factor receptor signaling pathway • nerve growth factor receptor signaling pathway
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 9:
17.58 – 17.8 Mb

Chr 4:
84.85 – 85.29 Mb

PubMed search

[1]

[2]

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.^[1]^[2]

Interactions

SH3GL2 has been shown to interact with DNM1,^[3]^[4] Amphiphysin,^[3]^[4] ADAM9,^[5] SH3KBP1^[6] and ADAM15.^[5]

References

^ Giachino C, Lantelme E, Lanzetti L, Saccone S, Bella Valle G, Migone N (Jul 1997). "A novel SH3-containing human gene family preferentially expressed in the central nervous system". Genomics 41 (3): 427–34. doi:10.1006/geno.1997.4645. PMID 9169142.
^ "Entrez Gene: SH3GL2 SH3-domain GRB2-like 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6456.
^ ^a ^b Micheva, K D; Kay B K, McPherson P S (Oct. 1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin". J. Biol. Chem. (UNITED STATES) 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. ISSN 0021-9258. PMID 9341169.
^ ^a ^b Modregger, Jan; Schmidt Anne A, Ritter Brigitte, Huttner Wieland B, Plomann Markus (Feb. 2003). "Characterization of Endophilin B1b, a brain-specific membrane-associated lysophosphatidic acid acyl transferase with properties distinct from endophilin A1". J. Biol. Chem. (United States) 278 (6): 4160–7. doi:10.1074/jbc.M208568200. ISSN 0021-9258. PMID 12456676.
^ ^a ^b Howard, L; Nelson K K, Maciewicz R A, Blobel C P (Oct. 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J. Biol. Chem. (UNITED STATES) 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. ISSN 0021-9258. PMID 10531379.
^ Soubeyran, Philippe; Kowanetz Katarzyna, Szymkiewicz Iwona, Langdon Wallace Y, Dikic Ivan (Mar. 2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors". Nature (England) 416 (6877): 183–7. doi:10.1038/416183a. ISSN 0028-0836. PMID 11894095.

Ren Y, Fang F, Davey F, Taylor M, Aiton J, Coote P, Yao J, Chen JX, Yan SD & Gunn-Moore FJ. (2008). "Endophilin I expression is increased in the brains of Alzheimer’s disease patients.". Journal of Biological Chemistry 283 (9): 5685–91. doi:10.1074/jbc.M707932200. PMID 18167351.
Reutens AT, Begley CG (2002). "Endophilin-1: a multifunctional protein.". Int. J. Biochem. Cell Biol. 34 (10): 1173–7. doi:10.1016/S1357-2725(02)00063-8. PMID 12127567.
So CW, Caldas C, Liu MM, et al. (1997). "EEN encodes for a member of a new family of proteins containing an Src homology 3 domain and is the third gene located on chromosome 19p13 that fuses to MLL in human leukemia.". Proc. Natl. Acad. Sci. U.S.A. 94 (6): 2563–8. doi:10.1073/pnas.94.6.2563. PMC 20128. PMID 9122235. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20128.
Ringstad N, Nemoto Y, De Camilli P (1997). "The SH3p4/Sh3p8/SH3p13 protein family: binding partners for synaptojanin and dynamin via a Grb2-like Src homology 3 domain.". Proc. Natl. Acad. Sci. U.S.A. 94 (16): 8569–74. doi:10.1073/pnas.94.16.8569. PMC 23017. PMID 9238017. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=23017.
Micheva KD, Ramjaun AR, Kay BK, McPherson PS (1997). "SH3 domain-dependent interactions of endophilin with amphiphysin.". FEBS Lett. 414 (2): 308–12. doi:10.1016/S0014-5793(97)01016-8. PMID 9315708.
Micheva KD, Kay BK, McPherson PS (1997). "Synaptojanin forms two separate complexes in the nerve terminal. Interactions with endophilin and amphiphysin.". J. Biol. Chem. 272 (43): 27239–45. doi:10.1074/jbc.272.43.27239. PMID 9341169.
Howard L, Nelson KK, Maciewicz RA, Blobel CP (1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.". J. Biol. Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
Tang Y, Hu LA, Miller WE, et al. (1999). "Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.". Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559–64. doi:10.1073/pnas.96.22.12559. PMC 22990. PMID 10535961. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=22990.
Cestra G, Castagnoli L, Dente L, et al. (1999). "The SH3 domains of endophilin and amphiphysin bind to the proline-rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.". J. Biol. Chem. 274 (45): 32001–7. doi:10.1074/jbc.274.45.32001. PMID 10542231.
So CW, So CK, Cheung N, et al. (2000). "The interaction between EEN and Abi-1, two MLL fusion partners, and synaptojanin and dynamin: implications for leukaemogenesis.". Leukemia 14 (4): 594–601. doi:10.1038/sj.leu.2401692. PMID 10764144.
So CW, Sham MH, Chew SL, et al. (2000). "Expression and protein-binding studies of the EEN gene family, new interacting partners for dynamin, synaptojanin and huntingtin proteins.". Biochem. J.. 348 Pt 2 (2): 447–58. doi:10.1042/0264-6021:3480447. PMC 1221085. PMID 10816441. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1221085.
Zucconi A, Dente L, Santonico E, et al. (2001). "Selection of ligands by panning of domain libraries displayed on phage lambda reveals new potential partners of synaptojanin 1.". J. Mol. Biol. 307 (5): 1329–39. doi:10.1006/jmbi.2001.4572. PMID 11292345.
Ramjaun AR, Angers A, Legendre-Guillemin V, et al. (2001). "Endophilin regulates JNK activation through its interaction with the germinal center kinase-like kinase.". J. Biol. Chem. 276 (31): 28913–9. doi:10.1074/jbc.M103198200. PMID 11384986.
Chen-Hwang MC, Chen HR, Elzinga M, Hwang YW (2002). "Dynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrate.". J. Biol. Chem. 277 (20): 17597–604. doi:10.1074/jbc.M111101200. PMID 11877424.
Soubeyran P, Kowanetz K, Szymkiewicz I, et al. (2002). "Cbl-CIN85-endophilin complex mediates ligand-induced downregulation of EGF receptors.". Nature 416 (6877): 183–7. doi:10.1038/416183a. PMID 11894095.
Petrelli A, Gilestro GF, Lanzardo S, et al. (2002). "The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met.". Nature 416 (6877): 187–90. doi:10.1038/416187a. PMID 11894096.
Chatellard-Causse C, Blot B, Cristina N, et al. (2002). "Alix (ALG-2-interacting protein X), a protein involved in apoptosis, binds to endophilins and induces cytoplasmic vacuolization.". J. Biol. Chem. 277 (32): 29108–15. doi:10.1074/jbc.M204019200. PMID 12034747.
Szymkiewicz I, Kowanetz K, Soubeyran P, et al. (2002). "CIN85 participates in Cbl-b-mediated down-regulation of receptor tyrosine kinases.". J. Biol. Chem. 277 (42): 39666–72. doi:10.1074/jbc.M205535200. PMID 12177062.
Haglund K, Shimokawa N, Szymkiewicz I, Dikic I (2002). "Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors.". Proc. Natl. Acad. Sci. U.S.A. 99 (19): 12191–6. doi:10.1073/pnas.192462299. PMC 129420. PMID 12218189. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129420.
Verstreken P, Kjaerulff O, Lloyd TE, et al. (2002). "Endophilin mutations block clathrin-mediated endocytosis but not neurotransmitter release.". Cell 109 (1): 101–12. doi:10.1016/S0092-8674(02)00688-8. PMID 11955450.

PDB gallery

1x03: Crystal structure of endophilin BAR domain

1zww: Crystal structure of endophilin-A1 BAR domain

2c08: RAT ENDOPHILIN A1 BAR DOMAIN

2d4c: Crystal structure of the endophilin BAR domain mutant

2dbm: Solution structures of the SH3 domain of human SH3-containing GRB2-like protein 2

SH3GL2

Interactions

References

Further reading