SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha is a protein that in humans is encoded by the SGTA gene.[1][2][3] SGTA orthologs [4] have also been identified in several mammals for which complete genome data are available.
This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function.[3]
Interactions
SGTA has been shown to interact with Growth hormone receptor.[2]
References
Further reading
- Heavner GA, Audhya T, Goldstein G (1990). "Peptide analogs of thymopentin distinguish distinct thymopoietin receptor specificities on two human T cell lines". Regul. Pept. 27 (2): 257–62. doi:10.1016/0167-0115(90)90044-W. PMID 2158125.
- Geraghty RJ, Talbot KJ, Callahan M et al. (1994). "Cell type-dependence for Vpu function". J. Med. Primatol. 23 (2–3): 146–50. doi:10.1111/j.1600-0684.1994.tb00115.x. PMID 7966229.
- Cziepluch C, Kordes E, Poirey R et al. (1998). "Identification of a Novel Cellular TPR-Containing Protein, SGT, That Interacts with the Nonstructural Protein NS1 of Parvovirus H-1". J. Virol. 72 (5): 4149–56. PMC 109644. PMID 9557704. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=109644.
- Callahan MA, Handley MA, Lee YH et al. (1998). "Functional Interaction of Human Immunodeficiency Virus Type 1 Vpu and Gag with a Novel Member of the Tetratricopeptide Repeat Protein Family". J. Virol. 72 (6): 5189–97. PMC 110095. PMID 9573291. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=110095.
- Callahan MA, Handley MA, Lee YH et al. (1998). "Functional interaction of human immunodeficiency virus type 1 Vpu and Gag with a novel member of the tetratricopeptide repeat protein family". J. Virol. 72 (10): 8461. PMID 9766974.
- Liu FH, Wu SJ, Hu SM et al. (1999). "Specific interaction of the 70-kDa heat shock cognate protein with the tetratricopeptide repeats". J. Biol. Chem. 274 (48): 34425–32. doi:10.1074/jbc.274.48.34425. PMID 10567422.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310948.
- Wiemann S, Weil B, Wellenreuther R et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=311072.
- Simpson JC, Wellenreuther R, Poustka A et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1083732.
- Handley MA, Paddock S, Dall A, Panganiban AT (2002). "Association of Vpu-binding protein with microtubules and Vpu-dependent redistribution of HIV-1 Gag protein". Virology 291 (2): 198–207. doi:10.1006/viro.2001.1166. PMID 11878889.
- Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Angeletti PC, Walker D, Panganiban AT (2003). "Small glutamine-rich protein/viral protein U–binding protein is a novel cochaperone that affects heat shock protein 70 activity". Cell Stress Chaperones 7 (3): 258–68. doi:10.1379/1466-1268(2002)007<0258:SGRPVP>2.0.CO;2. ISSN 1466-1268. PMC 514826. PMID 12482202. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514826.
- Pai MT, Yang CS, Tzeng SR et al. (2004). "1H, 15N and 13C resonance assignments of the tetratricopeptide repeat (TPR) domain of hSGT". J. Biomol. NMR 26 (4): 381–2. doi:10.1023/A:1024029117511. PMID 12815268.
- Wang H, Zhang Q, Zhu D (2004). "hSGT interacts with the N-terminal region of myostatin". Biochem. Biophys. Res. Commun. 311 (4): 877–83. doi:10.1016/j.bbrc.2003.10.080. PMID 14623262.
- Lehner B, Semple JI, Brown SE et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Winnefeld M, Rommelaere J, Cziepluch C (2004). "The human small glutamine-rich TPR-containing protein is required for progress through cell division". Exp. Cell Res. 293 (1): 43–57. doi:10.1016/j.yexcr.2003.09.028. PMID 14729056.
- Grimwood J, Gordon LA, Olsen A et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature 428 (6982): 529–35. doi:10.1038/nature02399. PMID 15057824.
- Beausoleil SA, Jedrychowski M, Schwartz D et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.