SGSM2

small G protein signaling modulator 2

Identifiers

SGSM2; KIAA0397; RUTBC1

External IDs

OMIM: 611418 MGI: 2144695 HomoloGene: 14780 GeneCards: SGSM2 Gene

Gene Ontology
Molecular function	• Rab GTPase activator activity
Cellular component	• intracellular
Biological process	• regulation of Rab GTPase activity
Sources: Amigo / QuickGO

Orthologs

Species

Human

Mouse

ENSG00000141258

ENSMUSG00000038351

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 17:
2.19 – 2.23 Mb

Chr 11:
74.66 – 74.71 Mb

PubMed search

Small G protein signaling modulator 2 is a protein that in humans is encoded by the SGSM2 gene.^[1]^[2]

Clinical relevance

In a recent genome-wide association study, this gene has been associated with fasting glucose traits, type 2 diabetes and obesity.^[3]

References

^ Yang, H; et al (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.". Genomics 90 (2): 249–260. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
^ "Entrez Gene: small G protein signaling modulator 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9905.
^ Strawbridge, RJ; et al (2011-08-26). "Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes.". Diabetes 60 (10): 2624–34. doi:10.2337/db11-0415. PMC 3178302. PMID 21873549. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3178302.

Further reading

Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Vasan RS, Glazer NL, Felix JF, et al. (2009). "Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.". JAMA 302 (2): 168–78. doi:10.1001/jama.2009.978-a. PMC 2975567. PMID 19584346. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2975567.
Ishikawa K, Nagase T, Nakajima D, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 4 (5): 307–13. doi:10.1093/dnares/4.5.307. PMID 9455477.
Yang H, Sasaki T, Minoshima S, Shimizu N (2007). "Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway.". Genomics 90 (2): 249–60. doi:10.1016/j.ygeno.2007.03.013. PMID 17509819.
Ishibashi K, Kanno E, Itoh T, Fukuda M (2009). "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity.". Genes Cells 14 (1): 41–52. doi:10.1111/j.1365-2443.2008.01251.x. PMID 19077034.