SFRS2IP

SR-related CTD-associated factor 11

Identifiers

SCAF11; CASP11; SFRS2IP; SIP1; SRRP129; SRSF2IP

External IDs

OMIM: 603668 MGI: 1919443 HomoloGene: 37957 GeneCards: SCAF11 Gene

Gene Ontology
Molecular function	• protein binding • zinc ion binding • metal ion binding
Cellular component	• nucleus
Biological process	• spliceosome assembly • RNA splicing, via transesterification reactions • mRNA processing • RNA splicing
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000139218

ENSMUSG00000033228

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 12:
46.32 – 46.39 Mb

Chr 15:
96.24 – 96.29 Mb

PubMed search

SFRS2-interacting protein is a protein that in humans is encoded by the SFRS2IP gene.^[1]^[2]^[3]

Interactions

SFRS2IP has been shown to interact with U2AF2.^[2]

References

^ Tanner S, Stagljar I, Georgiev O, Schaffner W, Bourquin JP (Aug 1997). "A novel SR-related protein specifically interacts with the carboxy-terminal domain (CTD) of RNA polymerase II through a conserved interaction domain". Biol Chem 378 (6): 565–71. PMID 9224939.
^ ^a ^b Zhang WJ, Wu JY (Feb 1998). "Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing". Mol Cell Biol 18 (2): 676–84. PMC 108778. PMID 9447963. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=108778.
^ "Entrez Gene: SFRS2IP splicing factor, arginine/serine-rich 2, interacting protein". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9169.

Further reading

Gui JF, Lane WS, Fu XD (1994). "A serine kinase regulates intracellular localization of splicing factors in the cell cycle.". Nature 369 (6482): 678–82. doi:10.1038/369678a0. PMID 8208298.
van de Craen M, de Jonghe C, van den Brande I, et al. (1999). "Identification of caspases that cleave presenilin-1 and presenilin-2. Five presenilin-1 (PS1) mutations do not alter the sensitivity of PS1 to caspases.". FEBS Lett. 445 (1): 149–54. doi:10.1016/S0014-5793(99)00108-8. PMID 10069390.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID 10508479.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.