SFRP4

Secreted frizzled-related protein 4

Identifiers

SFRP4; FRP-4; FRPHE; MGC26498

External IDs

OMIM: 606570 MGI: 892010 HomoloGene: 2267 GeneCards: SFRP4 Gene

Gene Ontology
Molecular function	• molecular_function • Wnt-protein binding • PDZ domain binding • Wnt receptor activity
Cellular component	• extracellular region • extracellular space • nucleus • cytoplasm • cell surface • neuron projection membrane
Biological process	• vasculature development • positive regulation of receptor internalization • axonogenesis • brain development • negative regulation of cell proliferation • gonad development • response to hormone stimulus • embryo development • positive regulation of gene expression • Wnt receptor signaling pathway • menstrual cycle phase • cell differentiation • response to estradiol stimulus • positive regulation of apoptosis • positive regulation of apoptosis • negative regulation of sequence-specific DNA binding transcription factor activity • response to peptide hormone stimulus • positive regulation of epidermal cell differentiation • negative regulation of JNK cascade • decidualization • response to glucocorticoid stimulus • phosphate ion homeostasis • mammary gland involution • epithelium development • negative regulation of canonical Wnt receptor signaling pathway • negative regulation of canonical Wnt receptor signaling pathway • positive regulation of canonical Wnt receptor signaling pathway • negative regulation of sodium-dependent phosphate transport
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
37.95 – 38.07 Mb

Chr 13:
19.71 – 19.72 Mb

PubMed search

[1]

[2]

Secreted frizzled-related protein 4 is a protein that in humans is encoded by the SFRP4 gene.^[1]^[2]

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.^[2]

References

^ Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, Kocher O (May 1999). "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy". Lab Invest 79 (4): 439–47. PMID 10211996.
^ ^a ^b "Entrez Gene: SFRP4 secreted frizzled-related protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6424.

Rattner A, Hsieh JC, Smallwood PM, et al. (1997). "A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors.". Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2859–63. doi:10.1073/pnas.94.7.2859. PMC 20287. PMID 9096311. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20287.
Wolf V, Ke G, Dharmarajan AM, et al. (1998). "DDC-4, an apoptosis-associated gene, is a secreted frizzled relative.". FEBS Lett. 417 (3): 385–9. doi:10.1016/S0014-5793(97)01324-0. PMID 9409757.
Schumann H, Holtz J, Zerkowski HR, Hatzfeld M (2000). "Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression.". Cardiovasc. Res. 45 (3): 720–8. doi:10.1016/S0008-6363(99)00376-4. PMID 10728394.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Berndt T, Craig TA, Bowe AE, et al. (2003). "Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.". J. Clin. Invest. 112 (5): 785–94. doi:10.1172/JCI200318563. PMC 182208. PMID 12952927. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=182208.
Wissmann C, Wild PJ, Kaiser S, et al. (2003). "WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer.". J. Pathol. 201 (2): 204–12. doi:10.1002/path.1449. PMID 14517837.
Horvath LG, Henshall SM, Kench JG, et al. (2004). "Membranous expression of secreted frizzled-related protein 4 predicts for good prognosis in localized prostate cancer and inhibits PC3 cellular proliferation in vitro.". Clin. Cancer Res. 10 (2): 615–25. doi:10.1158/1078-0432.CCR-0707-03. PMID 14760084.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ahn J, Chung KS, Kim DU, et al. (2005). "Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.". J. Biochem. Mol. Biol. 37 (6): 741–8. PMID 15607035.
He B, Lee AY, Dadfarmay S, et al. (2005). "Secreted frizzled-related protein 4 is silenced by hypermethylation and induces apoptosis in beta-catenin-deficient human mesothelioma cells.". Cancer Res. 65 (3): 743–8. PMID 15705870.
Berndt TJ, Bielesz B, Craig TA, et al. (2006). "Secreted frizzled-related protein-4 reduces sodium-phosphate co-transporter abundance and activity in proximal tubule cells.". Pflugers Arch. 451 (4): 579–87. doi:10.1007/s00424-005-1495-2. PMID 16151791.
Feng Han Q, Zhao W, Bentel J, et al. (2006). "Expression of sFRP-4 and beta-catenin in human colorectal carcinoma.". Cancer Lett. 231 (1): 129–37. doi:10.1016/j.canlet.2005.01.026. PMID 16356838.
Urakami S, Shiina H, Enokida H, et al. (2006). "Combination analysis of hypermethylated Wnt-antagonist family genes as a novel epigenetic biomarker panel for bladder cancer detection.". Clin. Cancer Res. 12 (7 Pt 1): 2109–16. doi:10.1158/1078-0432.CCR-05-2468. PMID 16609023.
Horvath LG, Lelliott JE, Kench JG, et al. (2007). "Secreted frizzled-related protein 4 inhibits proliferation and metastatic potential in prostate cancer.". Prostate 67 (10): 1081–90. doi:10.1002/pros.20607. PMID 17476687.

SFRP4

References

Further reading