SF3B3

Splicing factor 3b, subunit 3, 130kDa

Identifiers

SF3B3; KIAA0017; RSE1; SAP130; SF3b130; STAF130

External IDs

OMIM: 605592 MGI: 1289341 HomoloGene: 6579 GeneCards: SF3B3 Gene

Gene Ontology
Molecular function	• nucleic acid binding • protein binding
Cellular component	• nucleus • nucleoplasm • spliceosomal complex • U12-type spliceosomal complex • small nuclear ribonucleoprotein complex • catalytic step 2 spliceosome
Biological process	• RNA splicing, via transesterification reactions • nuclear mRNA splicing, via spliceosome • nuclear mRNA splicing, via spliceosome • mRNA processing • protein complex assembly • RNA splicing • gene expression
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
70.56 – 70.61 Mb

Chr 8:
113.33 – 113.37 Mb

PubMed search

[1]

[2]

Splicing factor 3B subunit 3 is a protein that in humans is encoded by the SF3B3 gene.^[1]^[2]

This gene encodes subunit 3 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 3 has also been identified as a component of the STAGA (SPT3-TAF(II)31-GCN5L acetylase) transcription coactivator-HAT (histone acetyltransferase) complex, and the TFTC (TATA-binding-protein-free TAF(II)-containing complex). These complexes may function in chromatin modification, transcription, splicing, and DNA repair.^[2]

Interactions

SF3B3 has been shown to interact with SF3B1,^[1]^[3] Transcription initiation protein SPT3 homolog^[4] and TAF9.^[4]

References

^ ^a ^b Das BK, Xia L, Palandjian L, Gozani O, Chyung Y, Reed R (Feb 2000). "Characterization of a Protein Complex Containing Spliceosomal Proteins SAPs 49, 130, 145, and 155". Mol Cell Biol 19 (10): 6796–802. PMC 84676. PMID 10490618. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=84676.
^ ^a ^b "Entrez Gene: SF3B3 splicing factor 3b, subunit 3, 130kDa". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23450.
^ Will, Cindy L; Urlaub Henning, Achsel Tilmann, Gentzel Marc, Wilm Matthias, Lührmann Reinhard (Sep. 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. (England) 21 (18): 4978–88. doi:10.1093/emboj/cdf480. ISSN 0261-4189. PMC 126279. PMID 12234937. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126279.
^ ^a ^b Martinez, E; Palhan V B, Tjernberg A, Lymar E S, Gamper A M, Kundu T K, Chait B T, Roeder R G (Oct. 2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. (United States) 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. ISSN 0270-7306. PMC 99856. PMID 11564863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856.

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Martinez E, Palhan VB, Tjernberg A, et al. (2001). "Human STAGA Complex Is a Chromatin-Acetylating Transcription Coactivator That Interacts with Pre-mRNA Splicing and DNA Damage-Binding Factors In Vivo". Mol. Cell. Biol. 21 (20): 6782–95. doi:10.1128/MCB.21.20.6782-6795.2001. PMC 99856. PMID 11564863. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=99856.
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Will CL, Urlaub H, Achsel T, et al. (2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126279.
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Li J, Hawkins IC, Harvey CD, et al. (2003). "Regulation of Alternative Splicing by SRrp86 and Its Interacting Proteins". Mol. Cell. Biol. 23 (21): 7437–47. doi:10.1128/MCB.23.21.7437-7447.2003. PMC 207616. PMID 14559993. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=207616.
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Will CL, Schneider C, Hossbach M, et al. (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370585.
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SF3B3

Interactions

References

Further reading