SERPINE2

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2

Identifiers

SERPINE2; DKFZp686A13110; GDN; PI-7; PI7; PN-1; PN1; PNI

External IDs

OMIM: 177010 MGI: 101780 HomoloGene: 21247 GeneCards: SERPINE2 Gene

Gene Ontology
Molecular function	• serine-type endopeptidase inhibitor activity • serine-type endopeptidase inhibitor activity • receptor binding • protein binding • glycosaminoglycan binding • heparin binding • peptidase inhibitor activity
Cellular component	• extracellular region • extracellular space • cytosol • extracellular matrix • platelet alpha granule • platelet alpha granule • extrinsic to external side of plasma membrane • neuromuscular junction
Biological process	• multicellular organismal development • nervous system development • negative regulation of plasminogen activation • negative regulation of endopeptidase activity • negative regulation of protein maturation by peptide bond cleavage • cell differentiation • negative regulation of blood coagulation • negative regulation of blood coagulation • regulation of cell migration • negative regulation of proteolysis • positive regulation of astrocyte differentiation • negative regulation of platelet aggregation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 2:
224.84 – 224.9 Mb

Chr 1:
79.79 – 79.86 Mb

PubMed search

[1]

[2]

Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.^[1]^[2]

1 See also
2 References
3 Further reading
4 External links

References

^ Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW (Oct 1995). "The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes". Genomics 27 (1): 196–9. doi:10.1006/geno.1995.1025. PMID 7665170.
^ "Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5270.

Naldini L, Tamagnone L, Vigna E et al. (1993). "Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor". EMBO J. 11 (13): 4825–33. PMC 556958. PMID 1334458. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=556958.
Gloor S, Odink K, Guenther J et al. (1987). "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins". Cell 47 (5): 687–93. doi:10.1016/0092-8674(86)90511-8. PMID 2877744.
Sommer J, Gloor SM, Rovelli GF et al. (1988). "cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily". Biochemistry 26 (20): 6407–10. doi:10.1021/bi00394a016. PMID 3427015.
Scott RW, Bergman BL, Bajpai A et al. (1985). "Protease nexin. Properties and a modified purification procedure". J. Biol. Chem. 260 (11): 7029–34. PMID 3997857.
Magnaldo T, Bernerd F, Darmon M (1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev. Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
Donovan FM, Vaughan PJ, Cunningham DD (1994). "Regulation of protease nexin-1 target protease specificity by collagen type IV". J. Biol. Chem. 269 (25): 17199–205. PMID 8006028.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Nykjaer A, Conese M, Christensen EI et al. (1997). "Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes". EMBO J. 16 (10): 2610–20. doi:10.1093/emboj/16.10.2610. PMC 1169872. PMID 9184208. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1169872.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
Grabham PW, Monard D, Gallimore PH, Grand RJ (1991). "Modulation of Human Neurite Outgrowth by Serine Proteases: A Comparison of the Interaction of Thrombin and Prothrombin with Glia-Derived Nexin". The European journal of neuroscience 3 (7): 663–668. doi:10.1111/j.1460-9568.1991.tb00852.x. PMID 12106474.
Crisp RJ, Knauer MF, Knauer DJ (2003). "Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV". J. Biol. Chem. 277 (49): 47285–91. doi:10.1074/jbc.M204813200. PMID 12356769.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Petrovic D, Milanez T, Kobal J et al. (2003). "Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction". Acta Neurol. Scand. 108 (2): 109–13. doi:10.1034/j.1600-0404.2003.00126.x. PMID 12859287.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2286551.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Kim JA, Tran ND, Li Z et al. (2006). "Brain endothelial hemostasis regulation by pericytes". J. Cereb. Blood Flow Metab. 26 (2): 209–17. doi:10.1038/sj.jcbfm.9600181. PMID 16015279.
Navaneetham D, Jin L, Pandey P et al. (2006). "Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2". J. Biol. Chem. 280 (43): 36165–75. doi:10.1074/jbc.M504990200. PMID 16085935.
Rual JF, Venkatesan K, Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

The MEROPS online database for peptidases and their inhibitors: I04.021
MeSH SERPINE2+protein,+human

Serpins

inhibitory	Alpha 1-antichymotrypsin · Alpha 1-antitrypsin · Alpha 2-antiplasmin · Antithrombin · C1-inhibitor · Heparin cofactor II · Protein C inhibitor · Plasminogen activator inhibitor-1 · Plasminogen activator inhibitor-2 · Protein Z-related protease inhibitor SERPINA1 · SERPINA2 · SERPINA3 · SERPINA4 · SERPINA5 · SERPINA6 · SERPINA7 · SERPINA8 · SERPINA9 · SERPINA14 SERPINB1 · SERPINB2 · SERPINB3 · SERPINB4 · SERPINB5 · SERPINB6 · SERPINB7 · SERPINB8 · SERPINB9 · SERPINB13 SERPINC1 · SERPIND1 · SERPINE1 · SERPINE2 · SERPINE2 · SERPINF1 · SERPING1 · SERPINH1 · SERPINI1 · SERPINI2

Cross class inhibitory	MENT · SCCA-1 · crmA

noninhibitory	Heat shock protein 47 · Maspin · Ovalbumin · SERPINF1 · Thyroxine-binding globulin · Transcortin · SERPINF1

see also disorders of globin and globulin proteins

SERPINE2

Contents

See also

References

Further reading

External links