SEPT9
Septin-9 is a protein that in humans is encoded by the SEPT9 gene.[1][2][3]
Interactions
SEPT9 has been shown to interact with SEPT2[4] and SEPT7.[4]
Biology
Along with AHNAK, eIF4E and S100A11, SEPT9 has been shown to be essential for pseudopod protrusion, tumor cell migration and invasion.[5]
Clinical Significance
The v2 region of the SEPT9 promoter has been shown to be methylated in colorectal cancer tissue compared with normal colonic mucosa.[6] Using highly sensitive real time PCR assays, methylated SEPT9 was detected in the blood of colorectal cancer patients.[7][8]
See also
References
- ^ Osaka M, Rowley JD, Zeleznik-Le NJ (Jun 1999). "MSF (MLL septin-like fusion), a fusion partner gene of MLL, in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)". Proc Natl Acad Sci U S A 96 (11): 6428–33. doi:10.1073/pnas.96.11.6428. PMC 26898. PMID 10339604. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=26898.
- ^ Taki T, Ohnishi H, Shinohara K, Sako M, Bessho F, Yanagisawa M, Hayashi Y (Sep 1999). "AF17q25, a putative septin family gene, fuses the MLL gene in acute myeloid leukemia with t(11;17)(q23;q25)". Cancer Res 59 (17): 4261–5. PMID 10485469.
- ^ "Entrez Gene: SEPT9 septin 9". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10801.
- ^ a b Surka, Mark C; Tsang Christopher W, Trimble William S (Oct. 2002). "The Mammalian Septin MSF Localizes with Microtubules and Is Required for Completion of Cytokinesis". Mol. Biol. Cell (United States) 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. ISSN 1059-1524. PMC 129964. PMID 12388755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129964.
- ^ Shankar, Jay; Messenberg A, Chan J, Underhill TM, Foster LJ, Nabi IR. (May 2010). "Pseudopodial actin dynamics control epithelial-mesenchymal transition in metastatic cancer cells". Cancer Res. 70 (9): 3780–90. doi:10.1158/0008-5472.CAN-09-4439. PMID 20388789.
- ^ http://www.transatlantic-symposium.de/content/_docs/doc1241003872263.pdf
- ^ Grutzmann, Robert; Molnar B, Pilarsky C, Habermann JK, Schlag PM, Saeger HD, Miehlke S, Stolz T, Model F, Roblick UJ, Bruch HP, Koch R, Liebenberg V, Devos T, Song X, Day RH, Sledziewski AZ, Lofton-Day C. (Nov. 2008). Najbauer, Joseph. ed. "Sensitive Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay". PLoS One 3 (11): 1–8. doi:10.1371/journal.pone.0003759. ISSN 1059-1524. PMC 2582436. PMID 19018278. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2582436.
- ^ deVos T, Tetzner R, Model F, Weiss G, Schuster M, Distler J, Steiger KV, Grützmann R, Pilarsky C, Habermann JK, Fleshner PR, Oubre BM, Day R, Sledziewski AZ, Lofton-Day C. (2009). "Circulating methylated SEPT9 DNA in plasma is a biomarker for colorectal cancer". Clin Chem. 55 (7): 1337–1346. doi:10.1373/clinchem.2008.115808. PMID 19406918.
Further reading
- Pellegrino JE, George RA, Biegel J, et al. (1998). "Hereditary neuralgic amyotrophy: evidence for genetic homogeneity and mapping to chromosome 17q25". Hum. Genet. 101 (3): 277–83. doi:10.1007/s004390050629. PMID 9439655.
- Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
- Medina M, Marinescu RC, Overhauser J, Kosik KS (2000). "Hemizygosity of delta-catenin (CTNND2) is associated with severe mental retardation in cri-du-chat syndrome". Genomics 63 (2): 157–64. doi:10.1006/geno.1999.6090. PMID 10673328.
- Kalikin LM, Sims HL, Petty EM (2000). "Genomic and expression analyses of alternatively spliced transcripts of the MLL septin-like fusion gene (MSF) that map to a 17q25 region of loss in breast and ovarian tumors". Genomics 63 (2): 165–72. doi:10.1006/geno.1999.6077. PMID 10673329.
- Russell SE, McIlhatton MA, Burrows JF, et al. (2000). "Isolation and mapping of a human septin gene to a region on chromosome 17q, commonly deleted in sporadic epithelial ovarian tumors". Cancer Res. 60 (17): 4729–34. PMID 10987277.
- McIlhatton MA, Burrows JF, Donaghy PG, et al. (2001). "Genomic organization, complex splicing pattern and expression of a human septin gene on chromosome 17q25.3". Oncogene 20 (41): 5930–9. doi:10.1038/sj.onc.1204752. PMID 11593400.
- Yamamoto K, Shibata F, Yamaguchi M, Miura O (2003). "Fusion of MLL and MSF in adult de novo acute myelomonocytic leukemia (M4) with t(11;17)(q23;q25)". Int. J. Hematol. 75 (5): 503–7. doi:10.1007/BF02982114. PMID 12095151.
- Surka MC, Tsang CW, Trimble WS (2003). "The Mammalian Septin MSF Localizes with Microtubules and Is Required for Completion of Cytokinesis". Mol. Biol. Cell 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129964.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Nagata K, Kawajiri A, Matsui S, et al. (2003). "Filament formation of MSF-A, a mammalian septin, in human mammary epithelial cells depends on interactions with microtubules". J. Biol. Chem. 278 (20): 18538–43. doi:10.1074/jbc.M205246200. PMID 12626509.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Nagata K, Asano T, Nozawa Y, Inagaki M (2005). "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11". J. Biol. Chem. 279 (53): 55895–904. doi:10.1074/jbc.M406153200. PMID 15485874.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Scott M, Hyland PL, McGregor G, et al. (2005). "Multimodality expression profiling shows SEPT9 to be overexpressed in a wide range of human tumours". Oncogene 24 (29): 4688–700. doi:10.1038/sj.onc.1208574. PMID 15782116.
- Ito H, Iwamoto I, Morishita R, et al. (2005). "Possible role of Rho/Rhotekin signaling in mammalian septin organization". Oncogene 24 (47): 7064–72. doi:10.1038/sj.onc.1208862. PMID 16007136.
- Scott M, McCluggage WG, Hillan KJ, et al. (2006). "Altered patterns of transcription of the septin gene, SEPT9, in ovarian tumorigenesis". Int. J. Cancer 118 (5): 1325–9. doi:10.1002/ijc.21486. PMID 16161048.
- Kuhlenbäumer G, Hannibal MC, Nelis E, et al. (2005). "Mutations in SEPT9 cause hereditary neuralgic amyotrophy". Nat. Genet. 37 (10): 1044–6. doi:10.1038/ng1649. PMID 16186812.