SEPT6

Septin 6

Identifiers

SEPT6; KIAA0128; MGC16619; MGC20339; SEP2; SEPT2

External IDs

OMIM: 300683 MGI: 1888939 HomoloGene: 62617 GeneCards: SEPT6 Gene

Gene Ontology
Molecular function	• nucleotide binding • protein binding • GTP binding
Cellular component	• condensed chromosome kinetochore • cellular_component • chromosome • cytoplasm • spindle • cytoskeleton • synaptic vesicle • midbody • septin complex • cleavage furrow • axon terminus
Biological process	• cytokinesis • cell cycle • interspecies interaction between organisms
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr X:
118.75 – 118.83 Mb

Chr X:
34.44 – 34.53 Mb

PubMed search

[1]

[2]

Septin-6 is a protein that in humans is encoded by the SEPT6 gene.^[1]^[2]^[3]

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.^[3]

Interactions

SEPT6 has been shown to interact with SEPT2.^[4]^[5]

References

^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (Mar 1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280.
^ Xue J, Wang X, Malladi CS, Kinoshita M, Milburn PJ, Lengyel I, Rostas JA, Robinson PJ (May 2000). "Phosphorylation of a new brain-specific septin, G-septin, by cGMP-dependent protein kinase". J Biol Chem 275 (14): 10047–56. doi:10.1074/jbc.275.14.10047. PMID 10744683.
^ ^a ^b "Entrez Gene: SEPT6 septin 6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23157.
^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
^ Surka, Mark C; Tsang Christopher W, Trimble William S (Oct. 2002). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis". Mol. Biol. Cell (United States) 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. ISSN 1059-1524. PMC 129964. PMID 12388755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129964.

Kinoshita A, Noda M, Kinoshita M (2000). "Differential localization of septins in the mouse brain.". J. Comp. Neurol. 428 (2): 223–39. doi:10.1002/1096-9861(20001211)428:2<223::AID-CNE3>3.0.CO;2-M. PMID 11064363.
Ono R, Taki T, Taketani T, et al. (2002). "SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24.". Cancer Res. 62 (2): 333–7. PMID 11809673.
Slater DJ, Hilgenfeld E, Rappaport EF, et al. (2002). "MLL-SEPTIN6 fusion recurs in novel translocation of chromosomes 3, X, and 11 in infant acute myelomonocytic leukaemia and in t(X;11) in infant acute myeloid leukaemia, and MLL genomic breakpoint in complex MLL-SEPTIN6 rearrangement is a DNA topoisomerase II cleavage site.". Oncogene 21 (30): 4706–14. doi:10.1038/sj.onc.1205572. PMID 12096348.
Surka MC, Tsang CW, Trimble WS (2003). "The mammalian septin MSF localizes with microtubules and is required for completion of cytokinesis.". Mol. Biol. Cell 13 (10): 3532–45. doi:10.1091/mbc.E02-01-0042. PMC 129964. PMID 12388755. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=129964.
Sheffield PJ, Oliver CJ, Kremer BE, et al. (2003). "Borg/septin interactions and the assembly of mammalian septin heterodimers, trimers, and filaments.". J. Biol. Chem. 278 (5): 3483–8. doi:10.1074/jbc.M209701200. PMID 12446710.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Vega IE, Hsu SC (2003). "The septin protein Nedd5 associates with both the exocyst complex and microtubules and disruption of its GTPase activity promotes aberrant neurite sprouting in PC12 cells.". Neuroreport 14 (1): 31–7. doi:10.1097/01.wnr.0000050304.92401.50. PMID 12544826.
Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Koshelev YA, Kiselev SL, Georgiev GP (2004). "Interaction of the S100A4 (Mts1) protein with septins Sept2, Sept6, and Sept7 in vitro.". Dokl. Biochem. Biophys. 391: 195–7. doi:10.1023/A:1025149005902. PMID 14531065.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMC 2665286. PMID 15772651. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2665286.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Kadkol SS, Bruno A, Oh S, et al. (2006). "MLL-SEPT6 fusion transcript with a novel sequence in an infant with acute myeloid leukemia.". Cancer Genet. Cytogenet. 168 (2): 162–7. doi:10.1016/j.cancergencyto.2006.02.020. PMID 16843108.
Low C, Macara IG (2006). "Structural analysis of septin 2, 6, and 7 complexes.". J. Biol. Chem. 281 (41): 30697–706. doi:10.1074/jbc.M605179200. PMID 16914550.
Kim CS, Seol SK, Song OK, et al. (2007). "An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication.". J. Virol. 81 (8): 3852–65. doi:10.1128/JVI.01311-06. PMC 1866118. PMID 17229681. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1866118.
Sirajuddin M, Farkasovsky M, Hauer F, et al. (2007). "Structural insight into filament formation by mammalian septins.". Nature 449 (7160): 311–5. doi:10.1038/nature06052. PMID 17637674.
Kremer BE, Adang LA, Macara IG (2007). "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7.". Cell 130 (5): 837–50. doi:10.1016/j.cell.2007.06.053. PMC 2085444. PMID 17803907. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2085444.

SEPT6

Interactions

References

Further reading