| Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SEMA4G; FLJ20590; KIAA1619; MGC102867 | ||||||||||||
| External IDs | MGI: 1347047 HomoloGene: 22682 GeneCards: SEMA4G Gene | ||||||||||||
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| RNA expression pattern | |||||||||||||
| More reference expression data | |||||||||||||
| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 57715 | 26456 | |||||||||||
| Ensembl | ENSG00000095539 | ENSMUSG00000025207 | |||||||||||
| UniProt | Q9NTN9 | Q9WUH7 | |||||||||||
| RefSeq (mRNA) | NM_001203244.1 | NM_011976.1 | |||||||||||
| RefSeq (protein) | NP_001190173.1 | NP_036106.1 | |||||||||||
| Location (UCSC) | Chr 10: 102.73 – 102.75 Mb |
Chr 19: 45.06 – 45.08 Mb |
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| PubMed search | [1] | [2] | |||||||||||
Semaphorin-4G is a protein that in humans is encoded by the SEMA4G gene.[1]
Semaphorins are a large family of conserved secreted and membrane associated proteins which possess a semaphorin (Sema) domain and a PSI domain (found in plexins, semaphorins and integrins) in the N-terminal extracellular portion. Based on sequence and structural similarities, semaphorins are put into eight classes: invertebrates contain classes 1 and 2, viruses have class V, and vertebrates contain classes 3-7. Semaphorins serve as axon guidance ligands via multimeric receptor complexes, some (if not all) containing plexin proteins. This gene encodes a class 4 semaphorin. This gene and the gene for mitochondrial ribosomal protein L43 overlap at map location 10q24.31 and are transcribed in opposite directions.[1]