SEMA4A

Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A

Identifiers

SEMA4A; CORD10; FLJ12287; RP35; SEMAB; SEMB

External IDs

OMIM: 607292 MGI: 107560 HomoloGene: 8425 GeneCards: SEMA4A Gene

Gene Ontology
Molecular function	• receptor activity
Cellular component	• plasma membrane • integral to membrane
Biological process	• multicellular organismal development • nervous system development • axon guidance • cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
156.12 – 156.15 Mb

Chr 3:
88.24 – 88.27 Mb

PubMed search

[1]

[2]

Semaphorin-4A is a protein that in humans is encoded by the SEMA4A gene.^[1]^[2]

SEMA4A is a member of the semaphorin family of soluble and transmembrane proteins. Semaphorins are involved in guidance of axonal migration during neuronal development and in immune responses.[supplied by OMIM]^[2]

References

^ Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron 14 (5): 941–8. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
^ ^a ^b "Entrez Gene: SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64218.

Kikutani H, Kumanogoh A (2003). "Semaphorins in interactions between T cells and antigen-presenting cells.". Nat. Rev. Immunol. 3 (2): 159–67. doi:10.1038/nri1003. PMID 12563299.
Kumanogoh A, Kikutani H (2004). "Immune semaphorins: a new area of semaphorin research.". J. Cell. Sci. 116 (Pt 17): 3463–70. doi:10.1242/jcs.00674. PMID 12893810.
Elhabazi A, Marie-Cardine A, Chabbert-de Ponnat I, et al. (2004). "Structure and function of the immune semaphorin CD100/SEMA4D.". Crit. Rev. Immunol. 23 (1-2): 65–81. doi:10.1615/CritRevImmunol.v23.i12.40. PMID 12906260.
Kumanogoh A, Marukawa S, Suzuki K, et al. (2002). "Class IV semaphorin Sema4A enhances T-cell activation and interacts with Tim-2.". Nature 419 (6907): 629–33. doi:10.1038/nature01037. PMID 12374982.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Abid A, Ismail M, Mehdi SQ, Khaliq S (2006). "Identification of novel mutations in the SEMA4A gene associated with retinal degenerative diseases.". J. Med. Genet. 43 (4): 378–81. doi:10.1136/jmg.2005.035055. PMC 2563224. PMID 16199541. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2563224.

SEMA4A

References

Further reading