SEMA3C

Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

Identifiers

SEMA3C; SEMAE; SemE

External IDs

OMIM: 602645 MGI: 107557 HomoloGene: 36201 GeneCards: SEMA3C Gene

Gene Ontology
Molecular function	• receptor activity • semaphorin receptor binding
Cellular component	• extracellular region • extracellular space • membrane
Biological process	• neural crest cell migration • somitogenesis • blood vessel remodeling • outflow tract morphogenesis • cardiac right ventricle morphogenesis • pulmonary myocardium development • immune response • heart development • post-embryonic development • neural tube development • response to drug • limb bud formation • dichotomous subdivision of terminal units involved in salivary gland branching
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 7:
80.37 – 80.55 Mb

Chr 5:
17.08 – 17.24 Mb

PubMed search

[1]

[2]

Semaphorin-3C is a protein that in humans is encoded by the SEMA3C gene.^[1]^[2]^[3]

References

^ Puschel AW, Adams RH, Betz H (Jun 1995). "Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension". Neuron 14 (5): 941–948. doi:10.1016/0896-6273(95)90332-1. PMID 7748561.
^ Mangasser-Stephan K, Dooley S, Welter C, Mutschler W, Hanselmann RG (Jun 1997). "Identification of human semaphorin E gene expression in rheumatoid synovial cells by mRNA differential display". Biochem Biophys Res Commun 234 (1): 153–156. doi:10.1006/bbrc.1997.6607. PMID 9168980.
^ "Entrez Gene: SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10512.

Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Chen H, Chédotal A, He Z et al. (1997). "Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III". Neuron 19 (3): 547–559. doi:10.1016/S0896-6273(00)80371-2. PMID 9331348.
Yamada T, Endo R, Gotoh M, Hirohashi S (1998). "Identification of semaphorin E as a non-MDR drug resistance gene of human cancers". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14713–14718. doi:10.1073/pnas.94.26.14713. PMC 25101. PMID 9405678. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=25101.
Galani E, Sgouros J, Petropoulou C et al. (2002). "Correlation of MDR-1, nm23-H1 and H Sema E gene expression with histopathological findings and clinical outcome in ovarian and breast cancer patients". Anticancer Res. 22 (4): 2275–80. PMID 12174914.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Scherer SW, Cheung J, MacDonald JR et al. (2003). "Human chromosome 7: DNA sequence and biology". Science 300 (5620): 767–772. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961.
Rieger J, Wick W, Weller M (2003). "Human malignant glioma cells express semaphorins and their receptors, neuropilins and plexins". Glia 42 (4): 379–389. doi:10.1002/glia.10210. PMID 12730958.
Hillier LW, Fulton RS, Fulton LA et al. (2003). "The DNA sequence of human chromosome 7". Nature 424 (6945): 157–164. doi:10.1038/nature01782. PMID 12853948.
Miller LE, Weidler C, Falk W et al. (2004). "Increased prevalence of semaphorin 3C, a repellent of sympathetic nerve fibers, in the synovial tissue of patients with rheumatoid arthritis". Arthritis Rheum. 50 (4): 1156–1163. doi:10.1002/art.20110. PMID 15077297.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Beckers J, Herrmann F, Rieger S et al. (2005). "Identification and validation of novel ERBB2 (HER2, NEU) targets including genes involved in angiogenesis". Int. J. Cancer 114 (4): 590–597. doi:10.1002/ijc.20798. PMID 15609325.
Herman JG, Meadows GG (2007). "Increased class 3 semaphorin expression modulates the invasive and adhesive properties of prostate cancer cells". Int. J. Oncol. 30 (5): 1231–8. PMID 17390026.

SEMA3C

References

Further reading