Nav1.9

sodium channel, voltage-gated, type XI, alpha subunit
Identifiers
Symbols SCN11A; NaN; SCN12A
External IDs OMIM: 604385 MGI: 1345149 HomoloGene: 8041 IUPHAR: Nav1.9 GeneCards: SCN11A Gene
Orthologs
Species Human Mouse
Entrez 11280 24046
Ensembl ENSG00000168356 ENSMUSG00000034115
UniProt Q9UI33 Q810E1
RefSeq (mRNA) NM_014139 NM_011887
RefSeq (protein) NP_054858 NP_036017
Location (UCSC) Chr 3:
38.86 – 38.97 Mb		 Chr 9:
119.66 – 119.73 Mb
PubMed search [1] [2]

Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated sodium ion channel protein which in humans is encoded by the SCN11A gene.[1][2]

References

  1. ^ Dib-Hajj S, Black JA, Cummins TR, Waxman SG (2002). "NaN/Nav1.9: a sodium channel with unique properties". Trends Neurosci. 25 (5): 253–9. doi:10.1016/S0166-2236(02)02150-1. PMID 11972962. 
  2. ^ Dib-Hajj SD, Tyrrell L, Waxman SG (2002). "Structure of the sodium channel gene SCN11A: evidence for intron-to-exon conversion model and implications for gene evolution". Mol. Neurobiol. 26 (2–3): 235–50. doi:10.1385/MN:26:2-3:235. PMID 12428758. 

Further reading

  • Delmas P, Coste B (2003). "Na+ channel Nav1.9: in search of a gating mechanism". Trends Neurosci. 26 (2): 55–7. doi:10.1016/S0166-2236(02)00030-9. PMID 12536125. 
  • Blum R, Kafitz KW, Konnerth A (2002). "Neurotrophin-evoked depolarization requires the sodium channel Na(V)1.9". Nature 419 (6908): 687–93. doi:10.1038/nature01085. PMID 12384689. 
  • Raymond CK, Castle J, Garrett-Engele P et al. (2004). "Expression of alternatively spliced sodium channel alpha-subunit genes. Unique splicing patterns are observed in dorsal root ganglia". J. Biol. Chem. 279 (44): 46234–41. doi:10.1074/jbc.M406387200. PMID 15302875. 
  • Dib-Hajj SD, Tyrrell L, Escayg A et al. (1999). "Coding sequence, genomic organization, and conserved chromosomal localization of the mouse gene Scn11a encoding the sodium channel NaN". Genomics 59 (3): 309–18. doi:10.1006/geno.1999.5890. PMID 10444332. 
  • Dib-Hajj SD, Tyrrell L, Cummins TR et al. (1999). "Two tetrodotoxin-resistant sodium channels in human dorsal root ganglion neurons". FEBS Lett. 462 (1–2): 117–20. doi:10.1016/S0014-5793(99)01519-7. PMID 10580103. 
  • Jeong SY, Goto J, Hashida H et al. (2000). "Identification of a novel human voltage-gated sodium channel alpha subunit gene, SCN12A". Biochem. Biophys. Res. Commun. 267 (1): 262–70. doi:10.1006/bbrc.1999.1916. PMID 10623608. 
  • Goldin AL, Barchi RL, Caldwell JH et al. (2000). "Nomenclature of voltage-gated sodium channels". Neuron 28 (2): 365–8. doi:10.1016/S0896-6273(00)00116-1. PMID 11144347. 
  • Catterall WA, Goldin AL, Waxman SG (2005). "International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels". Pharmacol. Rev. 57 (4): 397–409. doi:10.1124/pr.57.4.4. PMID 16382098. 

External links