SCG2

Secretogranin II
Identifiers
Symbols SCG2; CHGC; SN; SgII
External IDs OMIM118930 MGI103033 HomoloGene2591 GeneCards: SCG2 Gene
Orthologs
Species Human Mouse
Entrez 7857 20254
Ensembl ENSG00000171951 ENSMUSG00000050711
UniProt P13521 Q03517
RefSeq (mRNA) NM_003469 NM_009129.2
RefSeq (protein) NP_003460 NP_033155.1
Location (UCSC) Chr 2:
224.46 – 224.47 Mb
Chr 1:
79.43 – 79.44 Mb
PubMed search [1] [2]

SCG2, also called secretogranin II (chromogranin C), is a protein which in humans is encoded by the SCG2 gene.[1]

Contents

Function

The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. Studies in rodents suggest that the full-length protein, secretogranin II, is involved in the packaging or sorting of peptide hormones and neuropeptides into secretory vesicles. The full-length protein is cleaved to produce the active peptide secretoneurin, which exerts chemotaxic effects on specific cell types, and EM66, whose function is unknown.[2]

See also

Further reading

References

  1. ^ Gerdes HH, Rosa P, Phillips E, Baeuerle PA, Frank R, Argos P, Huttner WB (July 1989). "The primary structure of human secretogranin II, a widespread tyrosine-sulfated secretory granule protein that exhibits low pH- and calcium-induced aggregation". J. Biol. Chem. 264 (20): 12009–15. PMID 2745426. 
  2. ^ "Entrez Gene: SCG2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7857. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.