Special Boat Service, formerly Special Boat Section and Special Boat Squadron, a special forces unit of the British Royal Marines and formerly also of the Army Commandos and Special Air Service
Microsoft Small Business Server, now Windows Small Business Server, an integrated server suite from Microsoft designed for running network infrastructure of small and medium enterprises
Jive SBS, Jive Software's Social Business Software (formerly Clearspace)
Smart Battery System, a specification for determining accurate battery capacity readings
Music
Sky Blue Sky, an album by American rock band Wilco
Satellite Business Systems, a company founded by IBM, Aetna, Comsat, and later purchased by MCI that provided business-oriented satellite communications through its SBS fleet of geosynchronous satellites
Society for Biomolecular Sciences, an international non-profit scientific society dedicated to drug discovery and its related disciplines, based in Danbury, Connecticut, USA
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