S100A7

S100 calcium binding protein A7

PDB rendering based on 1psr.
Identifiers
Symbols S100A7; PSOR1; S100A7c
External IDs OMIM: 600353 HomoloGene: 48150 GeneCards: S100A7 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6278 n/a
Ensembl ENSG00000143556 n/a
UniProt P31151 n/a
RefSeq (mRNA) NM_002963.3 n/a
RefSeq (protein) NP_002954.2 n/a
Location (UCSC) Chr 1:
153.43 – 153.43 Mb		 n/a
PubMed search [1] n/a

Protein S100-A7 also known as S100 calcium-binding protein A7 or psoriasin is a protein that in humans is encoded by the S100A7 gene.[1]

Contents

Function

S100A7 is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein differs from the other S100 proteins of known structure in its lack of calcium binding ability in one EF-hand at the N-terminus. The protein functions as a prominent antimicrobial peptide mainly against E. coli.[2]

S100A7 is highly homologous to S100A15 (koebnerisin) but distinct in expression, tissue distribution and function.[3][4]

Clinical significance

This protein is markedly over-expressed in the skin lesions of psoriatic patients, but is excluded as a candidate gene for familial psoriasis susceptibility.[2]

Interactions

S100A7 has been shown to interact with COP9 constitutive photomorphogenic homolog subunit 5,[5] FABP5[6][7] and RANBP9.[8]

S100A7 interacts with RAGE (receptor of advanced glycated end products).[3]

References

  1. ^ Madsen P, Rasmussen HH, Leffers H, Honore B, Dejgaard K, Olsen E, Kiil J, Walbum E, Andersen AH, Basse B, et al. (Nov 1991). "Molecular cloning, occurrence, and expression of a novel partially secreted protein "psoriasin" that is highly up-regulated in psoriatic skin". J Invest Dermatol 97 (4): 701–12. doi:10.1111/1523-1747.ep12484041. PMID 1940442. 
  2. ^ a b "Entrez Gene: S100A7 S100 calcium binding protein A7". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6278. 
  3. ^ a b Wolf R, Howard OM, Dong HF, Voscopoulos C, Boeshans K, Winston J, Divi R, Gunsior M, Goldsmith P, Ahvazi B, Chavakis T, Oppenheim JJ, Yuspa SH (July 2008). "Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15". J. Immunol. 181 (2): 1499–506. PMC 2435511. PMID 18606705. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2435511. 
  4. ^ Wolf R, Voscopoulos C, Winston J, Dharamsi A, Goldsmith P, Gunsior M, Vonderhaar BK, Olson M, Watson PH, Yuspa SH (May 2009). "Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer". Cancer Lett. 277 (1): 101–7. doi:10.1016/j.canlet.2008.11.032. PMC 2680177. PMID 19136201. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2680177. 
  5. ^ Emberley, Ethan D; Niu Yulian, Leygue Etienne, Tomes Ladislav, Gietz R Daniel, Murphy Leigh C, Watson Peter H (Apr. 2003). "Psoriasin interacts with Jab1 and influences breast cancer progression". Cancer Res. (United States) 63 (8): 1954–61. ISSN 0008-5472. PMID 12702588. 
  6. ^ Ruse, Monica; Broome Ann-Marie, Eckert Richard L (Jul. 2003). "S100A7 (psoriasin) interacts with epidermal fatty acid binding protein and localizes in focal adhesion-like structures in cultured keratinocytes". J. Invest. Dermatol. (United States) 121 (1): 132–41. doi:10.1046/j.1523-1747.2003.12309.x. ISSN 0022-202X. PMID 12839573. 
  7. ^ Hagens, G; Roulin K, Hotz R, Saurat J H, Hellman U, Siegenthaler G (Feb. 1999). "Probable interaction between S100A7 and E-FABP in the cytosol of human keratinocytes from psoriatic scales". Mol. Cell. Biochem. (NETHERLANDS) 192 (1–2): 123–8. doi:10.1023/A:1006894909694. ISSN 0300-8177. PMID 10331666. 
  8. ^ Emberley, Ethan D; Gietz R Daniel, Campbell J Darren, HayGlass Kent T, Murphy Leigh C, Watson Peter H (Nov. 2002). "RanBPM interacts with psoriasin in vitro and their expression correlates with specific clinical features in vivo in breast cancer". BMC Cancer (England) 2: 28. doi:10.1186/1471-2407-2-28. PMC 137593. PMID 12421467. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=137593. 

Further reading