S100A6

S100 calcium binding protein A6

PDB rendering based on 1a03.
Identifiers
Symbols S100A6; 2A9; 5B10; CABP; CACY; PRA
External IDs OMIM114110 MGI1339467 HomoloGene7925 GeneCards: S100A6 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6277 20200
Ensembl ENSG00000197956 ENSMUSG00000001025
UniProt P06703 Q545I9
RefSeq (mRNA) NM_014624 NM_011313.2
RefSeq (protein) NP_055439 NP_035443.1
Location (UCSC) Chr 1:
153.51 – 153.51 Mb
Chr 3:
90.42 – 90.42 Mb
PubMed search [1] [2]

Protein S100-A6 is a protein that in humans is encoded by the S100A6 gene.[1]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-dependent insulin release, stimulation of prolactin secretion, and exocytosis. Chromosomal rearrangements and altered expression of this gene have been implicated in melanoma.[1]

Interactions

S100A6 has been shown to interact with S100B[2][3] and SUGT1.[4]

References

  1. ^ a b "Entrez Gene: S100A6 S100 calcium binding protein A6". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6277. 
  2. ^ Deloulme, J C; Assard N, Mbele G O, Mangin C, Kuwano R, Baudier J (Nov. 2000). "S100A6 and S100A11 are specific targets of the calcium- and zinc-binding S100B protein in vivo". J. Biol. Chem. (UNITED STATES) 275 (45): 35302–10. doi:10.1074/jbc.M003943200. ISSN 0021-9258. PMID 10913138. 
  3. ^ Yang, Q; O'Hanlon D, Heizmann C W, Marks A (Feb. 1999). "Demonstration of heterodimer formation between S100B and S100A6 in the yeast two-hybrid system and human melanoma". Exp. Cell Res. (UNITED STATES) 246 (2): 501–9. doi:10.1006/excr.1998.4314. ISSN 0014-4827. PMID 9925766. 
  4. ^ Nowotny, Marcin; Spiechowicz Magdalena, Jastrzebska Beata, Filipek Anna, Kitagawa Katsumi, Kuznicki Jacek (Jul. 2003). "Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins". J. Biol. Chem. (United States) 278 (29): 26923–8. doi:10.1074/jbc.M211518200. ISSN 0021-9258. PMID 12746458. 

Further reading