S100A5

S100 calcium binding protein A5

Rendering based on PDB 2KAX.

Available structures
PDB	2KAX, 2KAY

Identifiers

Symbols

S100A5; S100D

External IDs

OMIM: 176991 MGI: 1338915 HomoloGene: 2224 GeneCards: S100A5 Gene

Gene Ontology
Molecular function	• copper ion binding • calcium ion binding • zinc ion binding • protein homodimerization activity
Cellular component	• nucleus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
153.51 – 153.51 Mb

Chr 3:
90.41 – 90.42 Mb

PubMed search

[1]

[2]

Protein S100-A5 is a protein that in humans is encoded by the S100A5 gene.^[1]^[2]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein has a Ca²⁺ affinity 20- to 100-fold higher than the other S100 proteins studied under identical conditions. This protein also binds Zn²⁺ and Cu²⁺, and Cu²⁺ strongly which impairs the binding of Ca²⁺. This protein is expressed in very restricted regions of the adult brain.^[2]

References

^ Engelkamp D, Schafer BW, Mattei MG, Erne P, Heizmann CW (Aug 1993). "Six S100 genes are clustered on human chromosome 1q21: identification of two genes coding for the two previously unreported calcium-binding proteins S100D and S100E". Proc Natl Acad Sci U S A 90 (14): 6547–51. doi:10.1073/pnas.90.14.6547. PMC 46969. PMID 8341667. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=46969.
^ ^a ^b "Entrez Gene: S100A5 S100 calcium binding protein A5". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6276.

Schäfer BW, Heizmann CW (1996). "The S100 family of EF-hand calcium-binding proteins: functions and pathology". Trends Biochem. Sci. 21 (4): 134–40. PMID 8701470.
Schäfer BW, Wicki R, Engelkamp D et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
Ridinger K, Ilg EC, Niggli FK et al. (1999). "Clustered organization of S100 genes in human and mouse". Biochim. Biophys. Acta 1448 (2): 254–63. PMID 9920416.
Schäfer BW, Fritschy JM, Murmann P et al. (2000). "Brain S100A5 is a novel calcium-, zinc-, and copper ion-binding protein of the EF-hand superfamily". J. Biol. Chem. 275 (39): 30623–30. doi:10.1074/jbc.M002260200. PMID 10882717.
Bronckart Y, Decaestecker C, Nagy N et al. (2002). "Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins". Histol. Histopathol. 16 (3): 707–12. PMID 11510959.
Teratani T, Watanabe T, Yamahara K et al. (2002). "Restricted expression of calcium-binding protein S100A5 in human kidney". Biochem. Biophys. Res. Commun. 291 (3): 623–7. doi:10.1006/bbrc.2002.6494. PMID 11855835.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Chan WY, Xia CL, Dong DC et al. (2003). "Differential expression of S100 proteins in the developing human hippocampus and temporal cortex". Microsc. Res. Tech. 60 (6): 600–13. doi:10.1002/jemt.10302. PMID 12645008.
Gregory SG, Barlow KF, McLay KE et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.

S100A5

References

Further reading