S100A12

S100 calcium binding protein A12

PDB rendering based on 1e8a.

Available structures
PDB	1E8A, 1GQM, 1ODB, 2WC8, 2WCB, 2WCE, 2WCF

Identifiers

Symbols

S100A12; CAAF1; CAGC; CGRP; ENRAGE; MRP6; p6

External IDs

OMIM: 603112 HomoloGene: 48361 GeneCards: S100A12 Gene

Gene Ontology
Molecular function	• calcium ion binding • protein binding • zinc ion binding • RAGE receptor binding • RAGE receptor binding
Cellular component	• extracellular region • insoluble fraction • nucleus • cytoplasm • cytosol
Biological process	• xenobiotic metabolic process • inflammatory response • killing of cells of other organism • defense response to bacterium • positive regulation of I-kappaB kinase/NF-kappaB cascade • innate immune response • defense response to fungus
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

n/a

n/a

RefSeq (mRNA)

NM_005621

n/a

RefSeq (protein)

NP_005612

n/a

Location (UCSC)

Chr 1:
153.35 – 153.35 Mb

n/a

PubMed search

[1]

n/a

Protein S100-A12 is a protein that in humans is encoded by the S100A12 gene.^[1]^[2]

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities.^[2]

References

^ Wicki R, Marenholz I, Mischke D, Schafer BW, Heizmann CW (Mar 1997). "Characterization of the human S100A12 (calgranulin C, p6, CAAF1, CGRP) gene, a new member of the S100 gene cluster on chromosome 1q21". Cell Calcium 20 (6): 459–64. doi:10.1016/S0143-4160(96)90087-1. PMID 8985590.
^ ^a ^b "Entrez Gene: S100A12 S100 calcium binding protein A12". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6283.

Roth J, Vogl T, Sorg C, Sunderkötter C (2004). "Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules". Trends Immunol. 24 (4): 155–8. doi:10.1016/S1471-4906(03)00062-0. PMID 12697438.
Guignard F, Mauel J, Markert M (1995). "Identification and characterization of a novel human neutrophil protein related to the S100 family". Biochem. J. 309 ( Pt 2): 395–401. PMC 1135745. PMID 7626002. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1135745.
Schäfer BW, Wicki R, Engelkamp D et al. (1995). "Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family". Genomics 25 (3): 638–43. doi:10.1016/0888-7543(95)80005-7. PMID 7759097.
Yamamura T, Hitomi J, Nagasaki K et al. (1996). "Human CAAF1 gene--molecular cloning, gene structure, and chromosome mapping". Biochem. Biophys. Res. Commun. 221 (2): 356–60. doi:10.1006/bbrc.1996.0600. PMID 8619860.
Marti T, Erttmann KD, Gallin MY (1996). "Host-parasite interaction in human onchocerciasis: identification and sequence analysis of a novel human calgranulin". Biochem. Biophys. Res. Commun. 221 (2): 454–8. doi:10.1006/bbrc.1996.0616. PMID 8619876.
Ilg EC, Troxler H, Bürgisser DM et al. (1996). "Amino acid sequence determination of human S100A12 (P6, calgranulin C, CGRP, CAAF1) by tandem mass spectrometry". Biochem. Biophys. Res. Commun. 225 (1): 146–50. doi:10.1006/bbrc.1996.1144. PMID 8769108.
Hofmann MA, Drury S, Fu C et al. (1999). "RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100/calgranulin polypeptides". Cell 97 (7): 889–901. doi:10.1016/S0092-8674(00)80801-6. PMID 10399917.
Moroz OV, Antson AA, Dodson GG et al. (2000). "Crystallization and preliminary X-ray diffraction analysis of human calcium-binding protein S100A12". Acta Crystallogr. D Biol. Crystallogr. 56 (Pt 2): 189–91. doi:10.1107/S0907444999014936. PMID 10666601.
Moroz OV, Antson AA, Murshudov GN et al. (2001). "The three-dimensional structure of human S100A12". Acta Crystallogr. D Biol. Crystallogr. 57 (Pt 1): 20–9. doi:10.1107/S090744490001458X. PMID 11134923.
Cole AM, Kim YH, Tahk S et al. (2001). "Calcitermin, a novel antimicrobial peptide isolated from human airway secretions". FEBS Lett. 504 (1–2): 5–10. doi:10.1016/S0014-5793(01)02731-4. PMID 11522286.
Moroz OV, Antson AA, Dodson EJ et al. (2002). "The structure of S100A12 in a hexameric form and its proposed role in receptor signalling". Acta Crystallogr. D Biol. Crystallogr. 58 (Pt 3): 407–13. doi:10.1107/S0907444901021278. PMID 11856825.
Strauss GI, Edvinsson L, Larsen FS et al. (2002). "Circulating levels of neuropeptides (CGRP, VIP, NPY) in patients with fulminant hepatic failure". Neuropeptides 35 (3–4): 174–80. doi:10.1054/npep.2001.0861. PMID 11884208.
Maayan C, Becker Y, Gesundheit B, Girgis SI (2002). "Calcitonin gene related peptide in familial dysautonomia". Neuropeptides 35 (3–4): 189–95. doi:10.1054/npep.2001.0863. PMID 11884210.
Filipek A, Jastrzebska B, Nowotny M, Kuznicki J (2002). "CacyBP/SIP, a calcyclin and Siah-1-interacting protein, binds EF-hand proteins of the S100 family". J. Biol. Chem. 277 (32): 28848–52. doi:10.1074/jbc.M203602200. PMID 12042313.
Ryckman C, Robichaud GA, Roy J et al. (2002). "HIV-1 transcription and virus production are both accentuated by the proinflammatory myeloid-related proteins in human CD4+ T lymphocytes". J. Immunol. 169 (6): 3307–13. PMID 12218151.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Foell D, Ichida F, Vogl T et al. (2003). "S100A12 (EN-RAGE) in monitoring Kawasaki disease". Lancet 361 (9365): 1270–2. doi:10.1016/S0140-6736(03)12986-8. PMID 12699958.
Foell D, Kucharzik T, Kraft M et al. (2003). "Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease". Gut 52 (6): 847–53. doi:10.1136/gut.52.6.847. PMC 1773692. PMID 12740341. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1773692.

PDB gallery

1e8a: THE THREE-DIMENSIONAL STRUCTURE OF HUMAN S100A12

1gqm: THE STRUCTURE OF S100A12 IN A HEXAMERIC FORM

1odb: THE CRYSTAL STRUCTURE OF HUMAN S100A12 - COPPER COMPLEX

S100A12

References

Further reading