S100

S100 or S-100 can refer to:

• S-100 bus, a type of computer bus
• S-100 protein, a family of cellular antigens proteins
• Hondata s100, a engine tuning system for Honda and Acura cars
• QTEK S100, a re-badged HTC Magician Pocket PC phone
• USATC S100 Class, a 1942 0-6-0 steam locomotive class
• S-100, a predecessor to the S-200 Angara/Vega/Dubna surface-to-air missile system
• Canon Digital IXUS S100, a digital camera
• Guild S-100, a solid-body electric guitar