Ribosomal protein L4

Identifiers

External IDs

OMIM: 180479 MGI: 1915141 HomoloGene: 748 GeneCards: RPL4 Gene

Gene Ontology
Molecular function	• RNA binding • structural constituent of ribosome • protein binding
Cellular component	• nucleus • nucleolus • cytoplasm • cytosol • cytosol • cytosolic large ribosomal subunit • ribonucleoprotein complex
Biological process	• translation • translational elongation • translational termination • gene expression • viral reproduction • viral infectious cycle • viral transcription • endocrine pancreas development • cellular protein metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 15:
66.79 – 66.8 Mb

Chr 9:
64.02 – 64.03 Mb

PubMed search

[1]

[2]

60S ribosomal protein L4 is a protein that in humans is encoded by the RPL4 gene.^[1]^[2]^[3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L4E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

References

^ Kenmochi N, Kawaguchi T, Rozen S, Davis E, Goodman N, Hudson TJ, Tanaka T, Page DC (Aug 1998). "A map of 75 human ribosomal protein genes". Genome Res 8 (5): 509–23. doi:10.1101/gr.8.5.509. PMID 9582194.
^ Bagni C, Mariottini P, Annesi F, Amaldi F (Feb 1994). "Human ribosomal protein L4: cloning and sequencing of the cDNA and primary structure of the protein". Biochim Biophys Acta 1216 (3): 475–8. PMID 8268230.
^ ^a ^b "Entrez Gene: RPL4 ribosomal protein L4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6124.

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Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics.". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
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Ribosomal protein L4

References

Further reading