Reversine

Reversine

IUPAC name N'-cyclohexyl-N-(4-morpholinophenyl)-7H-purine-2,6-diamine
Identifiers
CAS number	656820-32-5
PubChem	210332
Jmol-3D images	Image 1
SMILES C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5
Properties
Molecular formula	C₂₁H₂₇N₇O
Molar mass	393.48538
Y (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Reversine, or 2-(4-morpholinoanilino)-6-cyclohexylaminopurine, is a small molecule developed by the group of Peter G. Schultz, used for stem cell dedifferentiation.

References

Chen S, Zhang Q, Wu X, Schultz PG, Ding S (2004) Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc., 126(2):410–411. [PMID 14719906]
Chen S, Takanashi S, Zhang Q, Xiong W, Zhu S, Peters EC, Ding S, Schultz PG (2007) Reversine increases the plasticity of lineage-committed mammalian cells. Proc Natl Acad Sci U S A. 104(25):10482-7. [PMID 17566101]

External links

2004 news story in C&E News