Replicative transposition

Replicative transposition is a mechanism of transposition in molecular biology, proposed by James A. Shapiro in 1979,[1] in which the transposable element is duplicated during the reaction, so that the transposing entity is a copy of the original element. In this mechanism, the donor and receptor DNA sequences form a characteristic intermediate "theta" configuration, sometimes called a "Shapiro intermediate".[2] Replicative transposition is characteristic to retrotransposons and occurs from time to time in class II transposons.Chaconas, George; Harshey, Rasika M. (2002), "Transposition of phage Mu DNA", in Craig, N. L.; Craigie, R.; Gellert, M. et al., Mobile DNA II, American Society for Microbiology, pp. 384–402, http://books.google.com/books?id=vRan2aXjiVcC&pg=PA384 .</ref>

References

  1. ^ Shapiro, J. A. (1979), "Molecular model for the transposition and replication of bacteriophage Mu and other transposable elements", Proceedings of the National Academy of Sciences of the United States of America 76 (4): 1933–1937, doi:10.1073/pnas.76.4.1933, PMC 383507, PMID 287033, http://www.pnas.org/content/76/4/1933.full.pdf .
  2. ^ Bushman, Frederic (2002), Lateral DNA transfer: mechanisms and consequences, CSHL Press, p. 46, ISBN 9780879696214, http://books.google.com/books?id=8oIaOGHURroC&pg=PA46 .