RAPSN

Receptor-associated protein of the synapse
Identifiers
Symbols RAPSN; MGC3597; RAPSYN; RNF205
External IDs OMIM601592 MGI99422 HomoloGene3708 GeneCards: RAPSN Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 5913 19400
Ensembl ENSG00000165917 ENSMUSG00000002104
UniProt Q13702 Q2M2N6
RefSeq (mRNA) NM_005055.4 NM_009023.3
RefSeq (protein) NP_005046.2 NP_033049.2
Location (UCSC) Chr 11:
47.46 – 47.47 Mb
Chr 2:
90.88 – 90.89 Mb
PubMed search [1] [2]

43 kDa receptor-associated protein of the synapse is a protein that in humans is encoded by the RAPSN gene.[1][2]

This protein belongs to a family of proteins that are receptor associated proteins of the synapse. It contains a conserved cAMP-dependent protein kinase phosphorylation site. It is believed to play some role in anchoring or stabilizing the nicotinic acetylcholine receptor at synaptic sites. It may link the receptor to the underlying postsynaptic cytoskeleton, possibly by direct association with actin or spectrin. Two splice variants have been identified for this gene.[2]

Interactions

RAPSN has been shown to interact with KHDRBS1.[3]

References

  1. ^ Buckel A, Beeson D, James M, Vincent A (Dec 1996). "Cloning of cDNA encoding human rapsyn and mapping of the RAPSN gene locus to chromosome 11p11.2-p11.1". Genomics 35 (3): 613–6. doi:10.1006/geno.1996.0409. PMID 8812503. 
  2. ^ a b "Entrez Gene: RAPSN receptor-associated protein of the synapse". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5913. 
  3. ^ Fung, E T; Lanahan A, Worley P, Huganir R L (Oct. 1998). "Identification of a Torpedo homolog of Sam68 that interacts with the synapse organizing protein rapsyn". FEBS Lett. (NETHERLANDS) 437 (1-2): 29–33. doi:10.1016/S0014-5793(98)01151-X. ISSN 0014-5793. PMID 9804166. 

Further reading