RSPO1

R-spondin 1
Identifiers
Symbols RSPO1; CRISTIN3; FLJ40906; RSPO
External IDs OMIM609595 MGI2183426 HomoloGene52148 GeneCards: RSPO1 Gene
Orthologs
Species Human Mouse
Entrez 284654 192199
Ensembl ENSG00000169218 ENSMUSG00000028871
UniProt Q2MKA7 B1ASC1
RefSeq (mRNA) NM_001038633.2 NM_138683.2
RefSeq (protein) NP_001033722.1 NP_619624.2
Location (UCSC) Chr 1:
38.08 – 38.1 Mb
Chr 4:
124.66 – 124.69 Mb
PubMed search [1] [2]

R-spondin-1 is a protein that in humans is encoded by the RSPO1 gene.[1]

This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.[1]

References

Further reading