RSPO1
R-spondin-1 is a protein that in humans is encoded by the RSPO1 gene.[1]
This gene is a member of the R-spondin family and encodes a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.[1]
References
Further reading
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Kamata T, Katsube K, Michikawa M, et al. (2004). "R-spondin, a novel gene with thrombospondin type 1 domain, was expressed in the dorsal neural tube and affected in Wnts mutants". Biochim. Biophys. Acta 1676 (1): 51–62. PMID 14732490.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
- Kim KA, Kakitani M, Zhao J, et al. (2005). "Mitogenic influence of human R-spondin1 on the intestinal epithelium". Science 309 (5738): 1256–9. doi:10.1126/science.1112521. PMID 16109882.
- Abraham C, Cho JH (2005). "Inducing intestinal growth". N. Engl. J. Med. 353 (21): 2297–9. doi:10.1056/NEJMcibr053367. PMID 16306530.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
- Parma P, Radi O, Vidal V, et al. (2007). "R-spondin1 is essential in sex determination, skin differentiation and malignancy". Nat. Genet. 38 (11): 1304–9. doi:10.1038/ng1907. PMID 17041600.
- Binnerts ME, Kim KA, Bright JM, et al. (2007). "R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6". Proc. Natl. Acad. Sci. U.S.A. 104 (37): 14700–5. doi:10.1073/pnas.0702305104. PMC 1965484. PMID 17804805. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1965484.