RRM1
Ribonucleoside-diphosphate reductase large subunit is an enzyme that in humans is encoded by the RRM1 gene.[1][2]
This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.[2]
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective Wikipedia articles. [3]
Fluorouracil (5-FU) Activity
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See also
References
Further reading
- Pavloff N, Rivard D, Masson S, et al. (1992). "Sequence analysis of the large and small subunits of human ribonucleotide reductase.". DNA Seq. 2 (4): 227–34. doi:10.3109/10425179209020807. PMID 1627826.
- Byrne J, Smith P (1991). "Human polymorphic probe pE1.8 detects SacI polymorphism in the ribonucleotide reductase M1 subunit gene.". Hum. Genet. 87 (3): 376. doi:10.1007/BF00200924. PMID 1677928.
- Parker NJ, Begley CG, Fox RM (1991). "Human M1 subunit of ribonucleotide reductase: cDNA sequence and expression in stimulated lymphocytes.". Nucleic Acids Res. 19 (13): 3741. doi:10.1093/nar/19.13.3741. PMC 328406. PMID 1840662. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=328406.
- Mann GJ, Musgrove EA, Fox RM, Thelander L (1988). "Ribonucleotide reductase M1 subunit in cellular proliferation, quiescence, and differentiation.". Cancer Res. 48 (18): 5151–6. PMID 3044582.
- Brissenden JE, Caras I, Thelander L, Francke U (1988). "The structural gene for the M1 subunit of ribonucleotide reductase maps to chromosome 11, band p15, in human and to chromosome 7 in mouse.". Exp. Cell Res. 174 (1): 302–8. doi:10.1016/0014-4827(88)90165-6. PMID 3275546.
- Engström Y, Francke U (1985). "Assignment of the structural gene for subunit M1 of human ribonucleotide reductase to the short arm of chromosome 11.". Exp. Cell Res. 158 (2): 477–83. doi:10.1016/0014-4827(85)90470-7. PMID 3891388.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Parker NJ, Begley CG, Fox RM (1994). "Human R1 subunit of ribonucleotide reductase (RRM1): 5' flanking region of the gene". Genomics 19 (1): 91–6. doi:10.1006/geno.1994.1017. PMID 8188248.
- Byrne JA, Smith PJ (1993). "The 11p15.5 ribonucleotide reductase M1 subunit locus is not imprinted in Wilms' tumour and hepatoblastoma". Hum. Genet. 91 (3): 275–7. doi:10.1007/BF00218271. PMID 8386696.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Bepler G, O'briant KC, Kim YC, et al. (1999). "A 1.4-Mb high-resolution physical map and contig of chromosome segment 11p15.5 and genes in the LOH11A metastasis suppressor region". Genomics 55 (2): 164–75. doi:10.1006/geno.1998.5659. PMID 9933563.
- Pitterle DM, Kim YC, Jolicoeur EM, et al. (1999). "Lung cancer and the human gene for ribonucleotide reductase subunit M1 (RRM1)". Mamm. Genome 10 (9): 916–22. doi:10.1007/s003359901114. PMID 10441745.
- Guittet O, Håkansson P, Voevodskaya N, et al. (2001). "Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells". J. Biol. Chem. 276 (44): 40647–51. doi:10.1074/jbc.M106088200. PMID 11517226.
- Kashlan OB, Scott CP, Lear JD, Cooperman BS (2002). "A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit". Biochemistry 41 (2): 462–74. doi:10.1021/bi011653a. PMID 11781084.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Kashlan OB, Cooperman BS (2003). "Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences". Biochemistry 42 (6): 1696–706. doi:10.1021/bi020634d. PMID 12578384.
- Xue L, Zhou B, Liu X, et al. (2003). "Wild-type p53 regulates human ribonucleotide reductase by protein-protein interaction with p53R2 as well as hRRM2 subunits". Cancer Res. 63 (5): 980–6. PMID 12615712.
- Gautam A, Li ZR, Bepler G (2003). "RRM1-induced metastasis suppression through PTEN-regulated pathways". Oncogene 22 (14): 2135–42. doi:10.1038/sj.onc.1206232. PMID 12687015.
- Rosell R, Scagliotti G, Danenberg KD, et al. (2003). "Transcripts in pretreatment biopsies from a three-arm randomized trial in metastatic non-small-cell lung cancer". Oncogene 22 (23): 3548–53. doi:10.1038/sj.onc.1206419. PMID 12789263.