RRAS2

Related RAS viral (r-ras) oncogene homolog 2

PDB rendering based on 2ery.

Available structures
PDB	2ery

Identifiers

Symbols

RRAS2; TC21

External IDs

OMIM: 600098 MGI: 1914172 HomoloGene: 6945 GeneCards: RRAS2 Gene

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • protein binding • GTP binding
Cellular component	• intracellular • endoplasmic reticulum • plasma membrane
Biological process	• GTP catabolic process • signal transduction • Ras protein signal transduction • cellular process • positive regulation of cell migration
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
14.3 – 14.39 Mb

Chr 7:
121.19 – 121.26 Mb

PubMed search

[1]

[2]

Ras-related protein R-Ras2 is a protein that in humans is encoded by the RRAS2 gene.^[1]^[2]^[3]

Interactions

RRAS2 has been shown to interact with C-Raf.^[4]^[5]

References

^ Drivas GT, Shih A, Coutavas E, Rush MG, D'Eustachio P (May 1990). "Characterization of four novel ras-like genes expressed in a human teratocarcinoma cell line". Mol Cell Biol 10 (4): 1793–8. PMC 362288. PMID 2108320. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=362288.
^ Chan AM, Miki T, Meyers KA, Aaronson SA (Sep 1994). "A human oncogene of the RAS superfamily unmasked by expression cDNA cloning". Proc Natl Acad Sci U S A 91 (16): 7558–62. doi:10.1073/pnas.91.16.7558. PMC 44441. PMID 8052619. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44441.
^ "Entrez Gene: RRAS2 related RAS viral (r-ras) oncogene homolog 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22800.
^ Li, W; Han M, Guan K L (Apr. 2000). "The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf". Genes Dev. (UNITED STATES) 14 (8): 895–900. ISSN 0890-9369. PMC 316541. PMID 10783161. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=316541.
^ Movilla, N; Crespo P, Bustelo X R (Oct. 1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins". Oncogene (ENGLAND) 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. ISSN 0950-9232. PMID 10557073.

Ehrhardt A, Ehrhardt GR, Guo X, Schrader JW (2002). "Ras and relatives--job sharing and networking keep an old family together.". Exp. Hematol. 30 (10): 1089–106. doi:10.1016/S0301-472X(02)00904-9. PMID 12384139.
Rosário M, Paterson HF, Marshall CJ (1999). "Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells.". EMBO J. 18 (5): 1270–9. doi:10.1093/emboj/18.5.1270. PMC 1171217. PMID 10064593. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171217.
Linnemann T, Geyer M, Jaitner BK, et al. (1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily.". J. Biol. Chem. 274 (19): 13556–62. doi:10.1074/jbc.274.19.13556. PMID 10224125.
Ehrhardt GR, Leslie KB, Lee F, et al. (1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: expression of a constitutively active mutant results in factor-independent growth of an interleukin-3-dependent cell line.". Blood 94 (7): 2433–44. PMID 10498616.
Movilla N, Crespo P, Bustelo XR (1999). "Signal transduction elements of TC21, an oncogenic member of the R-Ras subfamily of GTP-binding proteins.". Oncogene 18 (43): 5860–9. doi:10.1038/sj.onc.1202968. PMID 10557073.
Ohba Y, Mochizuki N, Yamashita S, et al. (2000). "Regulatory proteins of R-Ras, TC21/R-Ras2, and M-Ras/R-Ras3.". J. Biol. Chem. 275 (26): 20020–6. doi:10.1074/jbc.M000981200. PMID 10777492.
Figueroa C, Taylor J, Vojtek AB (2001). "Prenylated Rab acceptor protein is a receptor for prenylated small GTPases.". J. Biol. Chem. 276 (30): 28219–25. doi:10.1074/jbc.M101763200. PMID 11335720.
Murphy GA, Graham SM, Morita S, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation.". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587.
Rong R, He Q, Liu Y, et al. (2002). "TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway.". Oncogene 21 (7): 1062–70. doi:10.1038/sj.onc.1205154. PMID 11850823.
Ortiz-Vega S, Khokhlatchev A, Nedwidek M, et al. (2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1.". Oncogene 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Yuryev A, Wennogle LP (2003). "Novel raf kinase protein-protein interactions found by an exhaustive yeast two-hybrid analysis.". Genomics 81 (2): 112–25. doi:10.1016/S0888-7543(02)00008-3. PMID 12620389.
Mitin NY, Ramocki MB, Zullo AJ, et al. (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization.". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. doi:10.1073/pnas.0403413101. PMC 515085. PMID 15308774. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515085.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=515316.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621–5. doi:10.1126/science.1105776. PMID 15761153.

PDB gallery

2ery: The crystal structure of the Ras related protein RRas2 (RRAS2) in the GDP bound state

RRAS2

Interactions

References

Further reading