RPS29

Ribosomal protein S29
Identifiers
Symbols RPS29;
External IDs OMIM603633 HomoloGene83197 GeneCards: RPS29 Gene
Orthologs
Species Human Mouse
Entrez 6235 20090
Ensembl ENSG00000213741 n/a
UniProt P62273 n/a
RefSeq (mRNA) NM_001030001.1 NM_009093.2
RefSeq (protein) NP_001023.1 NP_033119.1
Location (UCSC) Chr 14:
50.04 – 50.05 Mb
n/a
PubMed search [1] [2]

40S ribosomal protein S29 is a protein that in humans is encoded by the RPS29 gene.[1][2][3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit and a member of the S14P family of ribosomal proteins. The protein, which contains a C2-C2 zinc finger-like domain that can bind to zinc, can enhance the tumor suppressor activity of Ras-related protein 1A (KREV1). It is located in the cytoplasm. Variable expression of this gene in colorectal cancers compared to adjacent normal tissues has been observed, although no correlation between the level of expression and the severity of the disease has been found. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.[3]

References

  1. ^ Kondoh N, Noda M, Fisher RJ, Schweinfest CW, Papas TS, Kondoh A, Samuel KP, Oikawa T (Oct 1996). "The S29 ribosomal protein increases tumor suppressor activity of K rev-1 gene on v-K ras-transformed NIH3T3 cells". Biochim Biophys Acta 1313 (1): 41–6. doi:10.1016/0167-4889(96)00052-3. PMID 8781548. 
  2. ^ Frigerio JM, Dagorn JC, Iovanna JL (Jul 1995). "Cloning, sequencing and expression of the L5, L21, L27a, L28, S5, S9, S10 and S29 human ribosomal protein mRNAs". Biochim Biophys Acta 1262 (1): 64–8. PMID 7772601. 
  3. ^ a b "Entrez Gene: RPS29 ribosomal protein S29". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6235. 

Further reading