RPS27

Ribosomal protein S27

Identifiers

RPS27; MPS-1; MPS1; S27

External IDs

OMIM: 603702 MGI: 1888676 HomoloGene: 803 GeneCards: RPS27 Gene

Gene Ontology
Molecular function	• DNA binding • structural constituent of ribosome • zinc ion binding • metal ion binding
Cellular component	• intracellular • nucleus • cytosol • cytosol • ribosome • cytosolic small ribosomal subunit
Biological process	• M phase of mitotic cell cycle • mitotic prometaphase • mitotic cell cycle • translation • translation • translation • translational elongation • translational termination • cell proliferation • gene expression • viral reproduction • viral infectious cycle • viral transcription • endocrine pancreas development • cellular protein metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 1:
153.96 – 153.96 Mb

Chr 9:
114.83 – 114.83 Mb

PubMed search

[1]

[2]

40S ribosomal protein S27 is a protein that in humans is encoded by the RPS27 gene.^[1]^[2]^[3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S27E family of ribosomal proteins. It contains a C4-type zinc finger domain that can bind to zinc. The encoded protein has been shown to be able to bind to nucleic acid. It is located in the cytoplasm as a ribosomal component, but it has also been detected in the nucleus. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.^[3]

References

^ Tsui SK, Lee SM, Fung KP, Waye MM, Lee CY (Mar 1997). "Primary structures and sequence analysis of human ribosomal proteins L39 and S27". Biochem Mol Biol Int 40 (3): 611–6. PMID 8908372.
^ Fernandez-Pol JA, Klos DJ, Hamilton PD (Nov 1993). "A growth factor-inducible gene encodes a novel nuclear protein with zinc finger structure". J Biol Chem 268 (28): 21198–204. PMID 8407955.
^ ^a ^b "Entrez Gene: RPS27 ribosomal protein S27 (metallopanstimulin 1)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6232.

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Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2253395.
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Bhonde MR, Hanski ML, Budczies J, et al. (2006). "DNA damage-induced expression of p53 suppresses mitotic checkpoint kinase hMps1: the lack of this suppression in p53MUT cells contributes to apoptosis". J. Biol. Chem. 281 (13): 8675–85. doi:10.1074/jbc.M511333200. PMID 16446370.
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RPS27

References

Further reading