RPS14

Ribosomal protein S14

Identifiers

RPS14; EMTB; S14

External IDs

OMIM: 130620 MGI: 98107 HomoloGene: 90926 GeneCards: RPS14 Gene

Gene Ontology
Molecular function	• RNA binding • structural constituent of ribosome • protein binding • translation regulator activity • mRNA 5'-UTR binding
Cellular component	• intracellular • nucleolus • mitochondrion • cytosol • cytosol • ribosome • cytosolic small ribosomal subunit
Biological process	• ribosomal small subunit assembly • ribosomal small subunit assembly • negative regulation of transcription from RNA polymerase II promoter • translation • translation • translation • translational elongation • translational termination • regulation of translation • gene expression • viral reproduction • viral infectious cycle • viral transcription • erythrocyte differentiation • maturation of SSU-rRNA • endocrine pancreas development • cellular protein metabolic process
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 5:
149.82 – 149.83 Mb

Chr 18:
60.93 – 60.94 Mb

PubMed search

[1]

[2]

40S ribosomal protein S14 is a protein that in humans is encoded by the RPS14 gene.^[1]^[2]^[3]

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S11P family of ribosomal proteins. It is located in the cytoplasm. Transcript variants utilizing alternative transcription initiation sites have been described in the literature. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. In Chinese hamster ovary cells, mutations in this gene can lead to resistance to emetine, a protein synthesis inhibitor. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.^[3]

References

^ Rhoads DD, Dixit A, Roufa DJ (Jan 1987). "Primary structure of human ribosomal protein S14 and the gene that encodes it". Mol Cell Biol 6 (8): 2774–83. PMC 367844. PMID 3785212. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=367844.
^ Diaz JJ, Roufa DJ (Apr 1992). "Fine-structure map of the human ribosomal protein gene RPS14". Mol Cell Biol 12 (4): 1680–6. PMC 369611. PMID 1549121. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=369611.
^ ^a ^b "Entrez Gene: RPS14 ribosomal protein S14". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6208.

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Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Yu Y, Ji H, Doudna JA, Leary JA (2005). "Mass spectrometric analysis of the human 40S ribosomal subunit: native and HCV IRES-bound complexes.". Protein Sci. 14 (6): 1438–46. doi:10.1110/ps.041293005. PMC 2253395. PMID 15883184. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2253395.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.

RPS14

References

Further reading