ROBO4

Roundabout homolog 4, magic roundabout (Drosophila)

Identifiers

ROBO4; ECSM4; FLJ20798; MGC133352; MGC133353; MRB

External IDs

OMIM: 607528 MGI: 1921394 HomoloGene: 10397 GeneCards: ROBO4 Gene

Gene Ontology
Molecular function	• receptor activity
Cellular component	• external side of plasma membrane • integral to membrane
Biological process	• angiogenesis • multicellular organismal development • cell differentiation • regulation of cell migration • negative regulation of cell migration
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

ENSG00000154133

ENSMUSG00000032125

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
124.75 – 124.77 Mb

Chr 9:
37.21 – 37.22 Mb

PubMed search

Roundabout homolog 4 is a protein that in humans is encoded by the ROBO4 gene.^[1]^[2]

References

^ Huminiecki L, Bicknell R (Dec 2000). "In silico cloning of novel endothelial-specific genes". Genome Res 10 (11): 1796–1806. doi:10.1101/gr.150700. PMC 310981. PMID 11076864. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=310981.
^ "Entrez Gene: ROBO4 roundabout homolog 4, magic roundabout (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54538.

Further reading

Schmucker D (2003). "Downstream of guidance receptors: entering the baroque period of axon guidance signaling". Neuron 40 (1): 4–6. doi:10.1016/S0896-6273(03)00603-2. PMID 14527427.
Huminiecki L, Gorn M, Suchting S et al. (2002). "Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis". Genomics 79 (4): 547–552. doi:10.1006/geno.2002.6745. PMID 11944987.
Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Park KW, Morrison CM, Sorensen LK et al. (2003). "Robo4 is a vascular-specific receptor that inhibits endothelial migration". Dev. Biol. 261 (1): 251–267. doi:10.1016/S0012-1606(03)00258-6. PMID 12941633.
Clark HF, Gurney AL, Abaya E et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.
Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Bedell VM, Yeo SY, Park KW et al. (2005). "roundabout4 is essential for angiogenesis in vivo". Proc. Natl. Acad. Sci. U.S.A. 102 (18): 6373–6378. doi:10.1073/pnas.0408318102. PMC 1088354. PMID 15849270. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1088354.
Seth P, Lin Y, Hanai J et al. (2005). "Magic roundabout, a tumor endothelial marker: expression and signaling". Biochem. Biophys. Res. Commun. 332 (2): 533–541. doi:10.1016/j.bbrc.2005.03.250. PMID 15894287.
Liu T, Qian WJ, Gritsenko MA et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–2080. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1850943.
Gröne J, Doebler O, Loddenkemper C et al. (2007). "Robo1/Robo4: differential expression of angiogenic markers in colorectal cancer". Oncol. Rep. 15 (6): 1437–43. PMID 16685377.
Okada Y, Yano K, Jin E et al. (2007). "A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium". Circ. Res. 100 (12): 1712–1722. doi:10.1161/01.RES.0000269779.10644.dc. PMID 17495228.