ROBO3

Roundabout, axon guidance receptor, homolog 3 (Drosophila)

Identifiers

ROBO3; FLJ21044; HGPPS; HGPS; RBIG1; RIG1

External IDs

OMIM: 608630 MGI: 1343102 HomoloGene: 32119 GeneCards: ROBO3 Gene

Gene Ontology
Molecular function	• receptor activity
Cellular component	• membrane • integral to membrane
Biological process	• multicellular organismal development • nervous system development • axon guidance • axon guidance • axon midline choice point recognition • cell differentiation
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 11:
124.74 – 124.75 Mb

Chr 9:
37.22 – 37.24 Mb

PubMed search

[1]

[2]

Roundabout homolog 3 is a protein that in humans is encoded by the ROBO3 gene.^[1]^[2]

References

^ Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rub U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, MacDonald DB, Stigsby B, Plaitakis A, Dretakis EK, Gottlob I, Pieh C, Traboulsi EI, Wang Q, Wang L, Andrews C, Yamada K, Demer JL, Karim S, Alger JR, Geschwind DH, Deller T, Sicotte NL, Nelson SF, Baloh RW, Engle EC (Jun 2004). "Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis". Science 304 (5676): 1509–13. doi:10.1126/science.1096437. PMC 1618874. PMID 15105459. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1618874.
^ "Entrez Gene: ROBO3 roundabout, axon guidance receptor, homolog 3 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64221.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Yuan SS, Cox LA, Dasika GK, Lee EY (1999). "Cloning and functional studies of a novel gene aberrantly expressed in RB-deficient embryos.". Dev. Biol. 207 (1): 62–75. doi:10.1006/dbio.1998.9141. PMID 10049565.
Jen J, Coulin CJ, Bosley TM, et al. (2002). "Familial horizontal gaze palsy with progressive scoliosis maps to chromosome 11q23-25.". Neurology 59 (3): 432–5. PMID 12177379.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bosley TM, Salih MA, Jen JC, et al. (2006). "Neurologic features of horizontal gaze palsy and progressive scoliosis with mutations in ROBO3.". Neurology 64 (7): 1196–203. doi:10.1212/01.WNL.0000156349.01765.2B. PMID 15824346.
Camurri L, Mambetisaeva E, Davies D, et al. (2006). "Evidence for the existence of two Robo3 isoforms with divergent biochemical properties.". Mol. Cell. Neurosci. 30 (4): 485–93. doi:10.1016/j.mcn.2005.07.014. PMID 16226035.
Chan WM, Traboulsi EI, Arthur B, et al. (2006). "Horizontal gaze palsy with progressive scoliosis can result from compound heterozygous mutations in ROBO3.". J. Med. Genet. 43 (3): e11. doi:10.1136/jmg.2005.035436. PMC 2563249. PMID 16525029. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2563249.

ROBO3

References

Further reading