ROBO2

Roundabout, axon guidance receptor, homolog 2 (Drosophila)

PDB rendering based on 1uem.

Available structures
PDB	1UEM, 1UJT, 2EDJ

Identifiers

Symbols

ROBO2; KIAA1568; SAX3

External IDs

OMIM: 602431 MGI: 1890110 HomoloGene: 43188 GeneCards: ROBO2 Gene

Gene Ontology
Molecular function	• protein binding • axon guidance receptor activity • axon guidance receptor activity • identical protein binding • identical protein binding
Cellular component	• cell surface • membrane • integral to membrane • axolemma
Biological process	• metanephros development • ureteric bud development • homophilic cell adhesion • multicellular organismal development • axon guidance • axon guidance • axon guidance • central nervous system development • brain development • axon midline choice point recognition • spinal cord development • olfactory bulb interneuron development • cell differentiation • retinal ganglion cell axon guidance • cellular response to hormone stimulus • positive regulation of axonogenesis • negative regulation of negative chemotaxis • negative regulation of synaptogenesis • apoptosis involved in luteolysis
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

n/a

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 3:
75.96 – 77.7 Mb

Chr 16:
73.89 – 74.41 Mb

PubMed search

[1]

[2]

Roundabout homolog 2 is a protein that in humans is encoded by the ROBO2 gene.^[1]^[2]

References

^ Kidd T, Brose K, Mitchell KJ, Fetter RD, Tessier-Lavigne M, Goodman CS, Tear G (Feb 1998). "Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors". Cell 92 (2): 205–15. doi:10.1016/S0092-8674(00)80915-0. PMID 9458045.
^ "Entrez Gene: ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6092.

Brose K, Bland KS, Wang KH, et al. (1999). "Slit proteins bind Robo receptors and have an evolutionarily conserved role in repulsive axon guidance.". Cell 96 (6): 795–806. doi:10.1016/S0092-8674(00)80590-5. PMID 10102268.
Nguyen Ba-Charvet KT, Brose K, Marillat V, et al. (1999). "Slit2-Mediated chemorepulsion and collapse of developing forebrain axons.". Neuron 22 (3): 463–73. doi:10.1016/S0896-6273(00)80702-3. PMID 10197527.
Nagase T, Kikuno R, Nakayama M, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (4): 273–81. doi:10.1093/dnares/7.4.271. PMID 10997877.
Nguyen Ba-Charvet KT, Brose K, Ma L, et al. (2001). "Diversity and specificity of actions of Slit2 proteolytic fragments in axon guidance.". J. Neurosci. 21 (12): 4281–9. PMID 11404413.
Marillat V, Cases O, Nguyen-Ba-Charvet KT, et al. (2002). "Spatiotemporal expression patterns of slit and robo genes in the rat brain.". J. Comp. Neurol. 442 (2): 130–55. doi:10.1002/cne.10068. PMID 11754167.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Hivert B, Liu Z, Chuang CY, et al. (2003). "Robo1 and Robo2 are homophilic binding molecules that promote axonal growth.". Mol. Cell. Neurosci. 21 (4): 534–45. doi:10.1006/mcne.2002.1193. PMID 12504588.
Grieshammer U, Le Ma , Plump AS, et al. (2004). "SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.". Dev. Cell 6 (5): 709–17. doi:10.1016/S1534-5807(04)00108-X. PMID 15130495.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Yue Y, Grossmann B, Galetzka D, et al. (2007). "Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.". Genomics 88 (6): 772–8. doi:10.1016/j.ygeno.2006.05.011. PMID 16829019.
Lu W, van Eerde AM, Fan X, et al. (2007). "Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.". Am. J. Hum. Genet. 80 (4): 616–32. doi:10.1086/512735. PMC 1852714. PMID 17357069. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1852714.

PDB gallery

1uem: Solution Structure of the First Fibronectin Type III domain of human KIAA1568 Protein

1ujt: Solution structure of the second fibronectin Type III domain of human KIAA1568 protein

ROBO2

References

Further reading