RIPK3
Receptor-interacting serine/threonine-protein kinase 3 is an enzyme that in humans is encoded by the RIPK3 gene.[1][2][3]
The product of this gene is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, and contains a C-terminal domain unique from other RIP family members. The encoded protein is predominantly localized to the cytoplasm, and can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. It is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor.[3]
Interactions
RIPK3 has been shown to interact with RIPK1.[1]
References
- ^ a b Yu PW, Huang BC, Shen M, Quast J, Chan E, Xu X, Nolan GP, Payan DG, Luo Y (Jun 1999). "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB". Curr Biol 9 (10): 539–42. doi:10.1016/S0960-9822(99)80239-5. PMID 10339433.
- ^ Sun X, Lee J, Navas T, Baldwin DT, Stewart TA, Dixit VM (Jul 1999). "RIP3, a novel apoptosis-inducing kinase". J Biol Chem 274 (24): 16871–5. doi:10.1074/jbc.274.24.16871. PMID 10358032.
- ^ a b "Entrez Gene: RIPK3 receptor-interacting serine-threonine kinase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11035.
Further reading
- Kasof GM, Prosser JC, Liu D, et al. (2000). "The RIP-like kinase, RIP3, induces apoptosis and NF-kappaB nuclear translocation and localizes to mitochondria". FEBS Lett. 473 (3): 285–91. doi:10.1016/S0014-5793(00)01473-3. PMID 10818227.
- Sun X, Yin J, Starovasnik MA, et al. (2002). "Identification of a novel homotypic interaction motif required for the phosphorylation of receptor-interacting protein (RIP) by RIP3". J. Biol. Chem. 277 (11): 9505–11. doi:10.1074/jbc.M109488200. PMID 11734559.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
- Meylan E, Burns K, Hofmann K, et al. (2004). "RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation". Nat. Immunol. 5 (5): 503–7. doi:10.1038/ni1061. PMID 15064760.
- Yang Y, Ma J, Chen Y, Wu M (2004). "Nucleocytoplasmic shuttling of receptor-interacting protein 3 (RIP3): identification of novel nuclear export and import signals in RIP3". J. Biol. Chem. 279 (37): 38820–9. doi:10.1074/jbc.M401663200. PMID 15208320.
- Yang Y, Hu W, Feng S, et al. (2005). "RIP3 beta and RIP3 gamma, two novel splice variants of receptor-interacting protein 3 (RIP3), downregulate RIP3-induced apoptosis". Biochem. Biophys. Res. Commun. 332 (1): 181–7. doi:10.1016/j.bbrc.2005.04.114. PMID 15896315.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1356129.
- Zhao L, Wang G, Lu D, et al. (2006). "Homocysteine, hRIP3 and congenital cardiovascular malformations". Anat. Embryol. 211 (3): 203–12. doi:10.1007/s00429-005-0074-9. PMID 16429275.
- Feng S, Ma L, Yang Y, Wu M (2006). "Truncated RIP3 (tRIP3) acts upstream of FADD to induce apoptosis in the human hepatocellular carcinoma cell line QGY-7703". Biochem. Biophys. Res. Commun. 347 (3): 558–65. doi:10.1016/j.bbrc.2006.06.118. PMID 16844082.
- Ahn KS, Sethi G, Krishnan K, Aggarwal BB (2007). "Gamma-tocotrienol inhibits nuclear factor-kappaB signaling pathway through inhibition of receptor-interacting protein and TAK1 leading to suppression of antiapoptotic gene products and potentiation of apoptosis". J. Biol. Chem. 282 (1): 809–20. doi:10.1074/jbc.M610028200. PMID 17114179.