RIPK1

Receptor (TNFRSF)-interacting serine-threonine kinase 1
Identifiers
Symbols RIPK1; FLJ39204; RIP; RIP1
External IDs OMIM: 603453 MGI: 108212 HomoloGene: 2820 GeneCards: RIPK1 Gene
EC number 2.7.11.1
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 8737 19766
Ensembl ENSG00000137275 ENSMUSG00000021408
UniProt Q13546 Q60855
RefSeq (mRNA) NM_003804 NM_009068.3
RefSeq (protein) NP_003795 NP_033094.3
Location (UCSC) Chr 6:
3.06 – 3.12 Mb		 Chr 13:
34.09 – 34.13 Mb
PubMed search [1] [2]

Receptor-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the RIPK1 gene.[1][2][3]

Interactions

RIPK1 has been shown to interact with CA11,[4] RIPK3,[5] RNF11,[6] Baculoviral IAP repeat-containing protein 3,[7] CFLAR,[8][9] BIRC2,[7] Caspase 8,[7][9][10] RNF216,[11] TNFRSF1A,[2][12][13][14][15][16] Sequestosome 1,[17] TRAF2,[2][18][19][20] CRADD,[13][21] TRADD[2] and Ubiquitin C.[4][7][15][16][22]

References

  1. ^ Stanger BZ, Leder P, Lee TH, Kim E, Seed B (Jun 1995). "RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death". Cell 81 (4): 513–23. doi:10.1016/0092-8674(95)90072-1. PMID 7538908. 
  2. ^ a b c d Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV (Jun 1996). "TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex". Immunity 4 (4): 387–96. doi:10.1016/S1074-7613(00)80252-6. PMID 8612133. 
  3. ^ "Entrez Gene: RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8737. 
  4. ^ a b Liao, Wentao; Xiao Qi, Tchikov Vladimir, Fujita Ken-ichi, Yang Wensheng, Wincovitch Stephen, Garfield Susan, Conze Dietrich, El-Deiry Wafik S, Schütze Stefan, Srinivasula Srinivasa M (May. 2008). "CARP-2 is an endosome-associated ubiquitin protein ligase for RIP and regulates TNF-induced NF-κB activation". Curr. Biol. (England) 18 (9): 641–9. doi:10.1016/j.cub.2008.04.017. ISSN 0960-9822. PMC 2587165. PMID 18450452. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2587165. 
  5. ^ Yu, P W; Huang B C, Shen M, Quast J, Chan E, Xu X, Nolan G P, Payan D G, Luo Y (May. 1999). "Identification of RIP3, a RIP-like kinase that activates apoptosis and NFkappaB". Curr. Biol. (ENGLAND) 9 (10): 539–42. doi:10.1016/S0960-9822(99)80239-5. ISSN 0960-9822. PMID 10339433. 
  6. ^ Shembade, Noula; Parvatiyar Kislay, Harhaj Nicole S, Harhaj Edward W (Mar. 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-κB signalling". EMBO J. (England) 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2657574. 
  7. ^ a b c d Bertrand, Mathieu J M; Milutinovic Snezana, Dickson Kathleen M, Ho Wai Chi, Boudreault Alain, Durkin Jon, Gillard John W, Jaquith James B, Morris Stephen J, Barker Philip A (Jun. 2008). "cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination". Mol. Cell (United States) 30 (6): 689–700. doi:10.1016/j.molcel.2008.05.014. PMID 18570872. 
  8. ^ Kataoka, T; Budd R C, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J (Jun. 2000). "The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways". Curr. Biol. (ENGLAND) 10 (11): 640–8. doi:10.1016/S0960-9822(00)00512-1. ISSN 0960-9822. PMID 10837247. 
  9. ^ a b Chaudhary, P M; Eby M T, Jasmin A, Kumar A, Liu L, Hood L (Sep. 2000). "Activation of the NF-kappaB pathway by caspase 8 and its homologs". Oncogene (ENGLAND) 19 (39): 4451–60. doi:10.1038/sj.onc.1203812. ISSN 0950-9232. PMID 11002417. 
  10. ^ Oshima, Shigeru; Turer Emre E, Callahan Joseph A, Chai Sophia, Advincula Rommel, Barrera Julio, Shifrin Nataliya, Lee Bettina, Benedict Yen T S, Yen Benjamin, Woo Tammy, Malynn Barbara A, Ma Averil (Feb. 2009). "ABIN-1 is a Ubiquitin Sensor that Restricts Cell Death and Sustains Embryonic Development". Nature (England) 457 (7231): 906–9. doi:10.1038/nature07575. PMC 2642523. PMID 19060883. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2642523. 
  11. ^ Chen, Danying; Li Xiaoyan, Zhai Zhonghe, Shu Hong-Bing (May. 2002). "A novel zinc finger protein interacts with receptor-interacting protein (RIP) and inhibits tumor necrosis factor (TNF)- and IL1-induced NF-kappa B activation". J. Biol. Chem. (United States) 277 (18): 15985–91. doi:10.1074/jbc.M108675200. ISSN 0021-9258. PMID 11854271. 
  12. ^ Kim, J W; Choi E J, Joe C O (Sep. 2000). "Activation of death-inducing signaling complex (DISC) by pro-apoptotic C-terminal fragment of RIP". Oncogene (ENGLAND) 19 (39): 4491–9. doi:10.1038/sj.onc.1203796. ISSN 0950-9232. PMID 11002422. 
  13. ^ a b Duan, H; Dixit V M (Jan. 1997). "RAIDD is a new 'death' adaptor molecule". Nature (ENGLAND) 385 (6611): 86–9. doi:10.1038/385086a0. ISSN 0028-0836. PMID 8985253. 
  14. ^ Blankenship, John W; Varfolomeev Eugene, Goncharov Tatiana, Fedorova Anna V, Kirkpatrick Donald S, Izrael-Tomasevic Anita, Phu Lilian, Arnott David, Aghajan Mariam, Zobel Kerry, Bazan J Fernando, Fairbrother Wayne J, Deshayes Kurt, Vucic Domagoj (Jan. 2009). "Ubiquitin binding modulates IAP antagonist-stimulated proteasomal degradation of c-IAP1 and c-IAP2(1)". Biochem. J. (England) 417 (1): 149–60. doi:10.1042/BJ20081885. PMID 18939944. 
  15. ^ a b Newton, Kim; Matsumoto Marissa L, Wertz Ingrid E, Kirkpatrick Donald S, Lill Jennie R, Tan Jenille, Dugger Debra, Gordon Nathaniel, Sidhu Sachdev S, Fellouse Frederic A, Komuves Laszlo, French Dorothy M, Ferrando Ronald E, Lam Cynthia, Compaan Deanne, Yu Christine, Bosanac Ivan, Hymowitz Sarah G, Kelley Robert F, Dixit Vishva M (Aug. 2008). "Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies". Cell (United States) 134 (4): 668–78. doi:10.1016/j.cell.2008.07.039. PMID 18724939. 
  16. ^ a b Varfolomeev, Eugene; Goncharov Tatiana, Fedorova Anna V, Dynek Jasmin N, Zobel Kerry, Deshayes Kurt, Fairbrother Wayne J, Vucic Domagoj (Sep. 2008). "c-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activation". J. Biol. Chem. (United States) 283 (36): 24295–9. doi:10.1074/jbc.C800128200. ISSN 0021-9258. PMID 18621737. 
  17. ^ Sanz L, Sanchez P, Lallena MJ, Diaz-Meco MT, Moscat J (1999). "The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation". EMBO J 18 (11): 3044–53. doi:10.1093/emboj/18.11.3044. PMC 1171386. PMID 10356400. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171386. 
  18. ^ Takeuchi, M; Rothe M, Goeddel D V (Aug. 1996). "Anatomy of TRAF2. Distinct domains for nuclear factor-kappaB activation and association with tumor necrosis factor signaling proteins". J. Biol. Chem. (UNITED STATES) 271 (33): 19935–42. doi:10.1074/jbc.271.33.19935. ISSN 0021-9258. PMID 8702708. 
  19. ^ Tada, K; Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak T W, Yagita H, Okumura K, Yeh W C, Nakano H (Sep. 2001). "Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death". J. Biol. Chem. (United States) 276 (39): 36530–4. doi:10.1074/jbc.M104837200. ISSN 0021-9258. PMID 11479302. 
  20. ^ Malinin, N L; Boldin M P, Kovalenko A V, Wallach D (Feb. 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature (ENGLAND) 385 (6616): 540–4. doi:10.1038/385540a0. ISSN 0028-0836. PMID 9020361. 
  21. ^ Ahmad, M; Srinivasula S M, Wang L, Talanian R V, Litwack G, Fernandes-Alnemri T, Alnemri E S (Feb. 1997). "CRADD, a novel human apoptotic adaptor molecule for caspase-2, and FasL/tumor necrosis factor receptor-interacting protein RIP". Cancer Res. (UNITED STATES) 57 (4): 615–9. ISSN 0008-5472. PMID 9044836. 
  22. ^ Ma, Qi; Zhou Li, Shi Huili, Huo Keke (Jun. 2008). "NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation". Cell. Signal. (England) 20 (6): 1044–51. doi:10.1016/j.cellsig.2008.01.015. ISSN 0898-6568. PMID 18299187. 

Further reading