RING1

Ring finger protein 1

PDB rendering based on 2h0d.
Identifiers
Symbols RING1; RING1A; RNF1
External IDs OMIM: 602045 MGI: 1101770 HomoloGene: 68283 GeneCards: RING1 Gene
RNA expression pattern
More reference expression data
Orthologs
Species Human Mouse
Entrez 6015 19763
Ensembl ENSG00000204227 ENSMUSG00000024325
UniProt Q06587 O35730
RefSeq (mRNA) NM_002931 NM_009066.3
RefSeq (protein) NP_002922 NP_033092.3
Location (UCSC) Chr 6:
33.28 – 33.29 Mb		 Chr 17:
34.16 – 34.16 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase RING1 is an enzyme that in humans is encoded by the RING1 gene.[1][2]

This gene belongs to the RING finger family, members of which encode proteins characterized by a RING domain, a zinc-binding motif related to the zinc finger domain. The gene product can bind DNA and can act as a transcriptional repressor. It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group proteins BMI1, EDR1, and CBX4, and colocalizes with these proteins in large nuclear domains. It interacts with the CBX4 protein via its glycine-rich C-terminal domain. The gene maps to the HLA class II region, where it is contiguous with the RING finger genes FABGL and HKE4.[2]

Contents

Interactions

RING1 has been shown to interact with CBX8,[3] BMI1[4][5] and RYBP.[6][7]

References

  1. ^ Hanson IM, Poustka A, Trowsdale J (Aug 1991). "New genes in the class II region of the human major histocompatibility complex". Genomics 10 (2): 417–24. doi:10.1016/0888-7543(91)90327-B. PMID 1906426. 
  2. ^ a b "Entrez Gene: RING1 ring finger protein 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6015. 
  3. ^ Bárdos, J I; Saurin A J, Tissot C, Duprez E, Freemont P S (Sep. 2000). "HPC3 is a new human polycomb orthologue that interacts and associates with RING1 and Bmi1 and has transcriptional repression properties". J. Biol. Chem. (UNITED STATES) 275 (37): 28785–92. doi:10.1074/jbc.M001835200. ISSN 0021-9258. PMID 10825164. 
  4. ^ Satijn, D P; Gunster M J, van der Vlag J, Hamer K M, Schul W, Alkema M J, Saurin A J, Freemont P S, van Driel R, Otte A P (Jul. 1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Mol. Cell. Biol. (UNITED STATES) 17 (7): 4105–13. ISSN 0270-7306. PMC 232264. PMID 9199346. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=232264. 
  5. ^ Satijn, D P; Otte A P (Jan. 1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity". Mol. Cell. Biol. (UNITED STATES) 19 (1): 57–68. ISSN 0270-7306. PMC 83865. PMID 9858531. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=83865. 
  6. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct. 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
  7. ^ García, E; Marcos-Gutiérrez C, del Mar Lorente M, Moreno J C, Vidal M (Jun. 1999). "RYBP, a new repressor protein that interacts with components of the mammalian Polycomb complex, and with the transcription factor YY1". EMBO J. (ENGLAND) 18 (12): 3404–18. doi:10.1093/emboj/18.12.3404. ISSN 0261-4189. PMC 1171420. PMID 10369680. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1171420. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.