RICTOR
Rapamycin-insensitive companion of mTOR is a protein that in humans is encoded by the RICTOR gene.[1][2]
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004).[supplied by OMIM][2]
Interactions
RICTOR has been shown to interact with Mammalian target of rapamycin[3][4][5][6][7][8][9] and KIAA1303.[6]
References
- ^ Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (Dec 2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc Natl Acad Sci U S A 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- ^ a b "Entrez Gene: RICTOR rapamycin-insensitive companion of mTOR". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=253260.
- ^ Jacinto, Estela; Loewith Robbie, Schmidt Anja, Lin Shuo, Rüegg Markus A, Hall Alan, Hall Michael N (Nov. 2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol. (England) 6 (11): 1122–8. doi:10.1038/ncb1183. ISSN 1465-7392. PMID 15467718.
- ^ Sarbassov, D D; Ali Siraj M, Kim Do-Hyung, Guertin David A, Latek Robert R, Erdjument-Bromage Hediye, Tempst Paul, Sabatini David M (Jul. 2004). "Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton". Curr. Biol. (England) 14 (14): 1296–302. doi:10.1016/j.cub.2004.06.054. ISSN 0960-9822. PMID 15268862.
- ^ Frias, Maria A; Thoreen Carson C, Jaffe Jacob D, Schroder Wayne, Sculley Tom, Carr Steven A, Sabatini David M (Sep. 2006). "mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s". Curr. Biol. (England) 16 (18): 1865–70. doi:10.1016/j.cub.2006.08.001. ISSN 0960-9822. PMID 16919458.
- ^ a b Jacinto, Estela; Facchinetti Valeria, Liu Dou, Soto Nelyn, Wei Shiniu, Jung Sung Yun, Huang Qiaojia, Qin Jun, Su Bing (Oct. 2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell (United States) 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. ISSN 0092-8674. PMID 16962653.
- ^ Yang, Qian; Inoki Ken, Ikenoue Tsuneo, Guan Kun-Liang (Oct. 2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. (United States) 20 (20): 2820–32. doi:10.1101/gad.1461206. ISSN 0890-9369. PMC 1619946. PMID 17043309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1619946.
- ^ Sarbassov, Dos D; Ali Siraj M, Sengupta Shomit, Sheen Joon-Ho, Hsu Peggy P, Bagley Alex F, Markhard Andrew L, Sabatini David M (Apr. 2006). "Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB". Mol. Cell (United States) 22 (2): 159–68. doi:10.1016/j.molcel.2006.03.029. ISSN 1097-2765. PMID 16603397.
- ^ Sarbassov, Dos D; Sabatini David M (Nov. 2005). "Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex". J. Biol. Chem. (United States) 280 (47): 39505–9. doi:10.1074/jbc.M506096200. ISSN 0021-9258. PMID 16183647.
Further reading
- Cohen D, Scribner R, Clark J, Cory D (1992). "The potential role of custody facilities in controlling sexually transmitted diseases". American journal of public health 82 (4): 552–6. doi:10.2105/AJPH.82.4.552. PMC 1694115. PMID 1546771. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1694115.
- Ohara O, Nagase T, Mitsui G, et al. (2003). "Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method". DNA Res. 9 (2): 47–57. doi:10.1093/dnares/9.2.47. PMID 12056414.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Sarbassov DD, Ali SM, Kim DH, et al. (2004). "Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton". Curr. Biol. 14 (14): 1296–302. doi:10.1016/j.cub.2004.06.054. PMID 15268862.
- Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446.
- Jacinto E, Loewith R, Schmidt A, et al. (2004). "Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive". Nat. Cell Biol. 6 (11): 1122–8. doi:10.1038/ncb1183. PMID 15467718.
- Sarbassov DD, Guertin DA, Ali SM, Sabatini DM (2005). "Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex". Science 307 (5712): 1098–101. doi:10.1126/science.1106148. PMID 15718470.
- Kudchodkar SB, Yu Y, Maguire TG, Alwine JC (2006). "Human cytomegalovirus infection alters the substrate specificities and rapamycin sensitivities of raptor- and rictor-containing complexes". Proc. Natl. Acad. Sci. U.S.A. 103 (38): 14182–7. doi:10.1073/pnas.0605825103. PMC 1599931. PMID 16959881. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1599931.
- Jacinto E, Facchinetti V, Liu D, et al. (2006). "SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity". Cell 127 (1): 125–37. doi:10.1016/j.cell.2006.08.033. PMID 16962653.
- Yang Q, Inoki K, Ikenoue T, Guan KL (2006). "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity". Genes Dev. 20 (20): 2820–32. doi:10.1101/gad.1461206. PMC 1619946. PMID 17043309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1619946.
- Fuchs BC, Finger RE, Onan MC, Bode BP (2007). "ASCT2 silencing regulates mammalian target-of-rapamycin growth and survival signaling in human hepatoma cells". Am. J. Physiol., Cell Physiol. 293 (1): C55–63. doi:10.1152/ajpcell.00330.2006. PMID 17329400.
- Pearce LR, Huang X, Boudeau J, et al. (2007). "Identification of Protor as a novel Rictor-binding component of mTOR complex-2". Biochem. J. 405 (3): 513–22. doi:10.1042/BJ20070540. PMC 2267312. PMID 17461779. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2267312.