RHOT2

Ras homolog gene family, member T2

Identifiers

RHOT2; ARHT2; C16orf39; MIRO-2; RASL

External IDs

OMIM: 613889 MGI: 2384892 HomoloGene: 56038 GeneCards: RHOT2 Gene

3.6.5.-

Gene Ontology
Molecular function	• nucleotide binding • GTPase activity • calcium ion binding • protein binding • GTP binding • hydrolase activity
Cellular component	• intracellular • mitochondrion • mitochondrial outer membrane • mitochondrial inner membrane • cytosol • plasma membrane • integral to membrane • integral to mitochondrial outer membrane
Biological process	• apoptosis • small GTPase mediated signal transduction • cellular homeostasis • mitochondrion transport along microtubule • regulation of small GTPase mediated signal transduction
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 16:
0.72 – 0.72 Mb

Chr 17:
25.98 – 25.98 Mb

PubMed search

[1]

[2]

Mitochondrial Rho GTPase 2 is an enzyme that in humans is encoded by the RHOT2 gene.^[1]^[2]

Function

The gene homolog of RHOT2 in yeast codes for a protein called Gem1 that has been shown to be part of a complex of proteins that functions at points of contact between the endoplasmic reticulum and mitochondria.^[3]

References

^ Fransson A, Ruusala A, Aspenstrom P (Feb 2003). "Atypical Rho GTPases have roles in mitochondrial homeostasis and apoptosis". J Biol Chem 278 (8): 6495–502. doi:10.1074/jbc.M208609200. PMID 12482879.
^ "Entrez Gene: RHOT2 ras homolog gene family, member T2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=89941.
^ Kornmann, B.; Osman, C.; Walter, P. (2011). "The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections". Proceedings of the National Academy of Sciences 108 (34): 14151–14156. doi:10.1073/pnas.1111314108. PMC 3161550. PMID 21825164. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3161550. edit

Daniels RJ, Peden JF, Lloyd C, et al. (2001). "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.". Hum. Mol. Genet. 10 (4): 339–52. doi:10.1093/hmg/10.4.339. PMID 11157797.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Aspenström P, Fransson A, Saras J (2004). "Rho GTPases have diverse effects on the organization of the actin filament system.". Biochem. J. 377 (Pt 2): 327–37. doi:10.1042/BJ20031041. PMC 1223866. PMID 14521508. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1223866.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Shan Y, Hexige S, Guo Z, et al. (2004). "Cloning and characterization of the mouse Arht2 gene which encodes a putative atypical GTPase.". Cytogenet. Genome Res. 106 (1): 91–7. doi:10.1159/000078568. PMID 15218247.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442148.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Fransson S, Ruusala A, Aspenström P (2006). "The atypical Rho GTPases Miro-1 and Miro-2 have essential roles in mitochondrial trafficking.". Biochem. Biophys. Res. Commun. 344 (2): 500–10. doi:10.1016/j.bbrc.2006.03.163. PMID 16630562.

RHOT2

Function

References

Further reading